Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. 31231223

2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. 30591531

2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE All isolates were in vitro evaluated for their cytotoxic activity against seven lung cancer cell lines, in addition to antimicrobial activity for eight bacteria, scavenging potential using ABTS<sup>·+</sup> and DPPH test, and anti-inflammatory activity for Cox-1 and Cox-2 which had not previously been tested for crinane-type alkaloids with the cleavage between C-1 and C-13. 30114468

2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE The THP-1, monocytic leukemia cell line effectively absorbed COX-2 by lung cancer cell-derived exosomes. 29345286

2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer: A PRISMA-compliant meta-analysis. 30170377

2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE BPA induced COX-2 expression via nuclear translocation of NF-κB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells. 28709031

2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Tissue microarray immunohistochemical analysis was performed to assess the correlation between NMI and COX-2 expression in lung cancer patients. 29025423

2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Further investigations showed that the PI3K/Akt signalling pathway and COX-2 are involved in endothelial tube formation under the stimulation of lung cancer cells. 28173828

2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. 28150906

2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE CONCLUSIONS In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer, while rs2066826 may increase the risk of lung cancer. 26624903

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. 25465874

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE In the present study, the ability of meloxicam, a COX-2-specific inhibitor to enhance doxorubicin‑mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro. 26600514

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer. 26744864

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Thus, COX-2 is likely important in lung tumorigenesis, and COX-2 and its product, PGE2, are potential targets for lung cancer prevention. 26452035

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX‑2, has been observed in lung cancer tissue. 24337484

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway. 24909729

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Our study provides pharmacological evidence that CS-6 exhibits potential use in the treatment of COX-2-mediated diseases such as lung cancer. 25175164

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Interestingly, COX-2 is overexpressed in numerous cancers, including lung cancer. 25047043

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Moreover, downregulation of COX-2/PGE2 and MIG-7 significantly prolonged the overall and disease-free survival of lung cancer-bearing mice. 25004182

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1. 24098479

2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. 23943857

2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC. 22160576

2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE p38 MAPK, ERK, and COX-2 activation are novel mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer. 22696230

2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE Taken together, this meta-analysis suggests that the COX 2 T8473C polymorphism is not associated with lung cancer risk. 22292629

2011
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE However, the regulatory mechanism underlying COX-2 overexpression in lung cancer is not fully understood. 21678473

2011