Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE Patients with abdominal nodal disease had inferior lymphoma specific survival (p=0.04) and presented with higher age adjusted IPI (p<0.001), lactate dehydrogenase (p<0.001) and more often advanced stage (p<0.001), bulky disease (p<0.001), B-symptoms (p<0.001), and double expression of MYC and BCL2 (p=0.02) compared to patients without nodal abdominal involvement, but less often extranodal involvement (p<0.02). 31785002

2020

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Overexpression of SMYD2 was validated in vivo but the functional analysis was constrained by in vitro loss of p53 in RUNX2/MYC lymphoma cell lines. 31257681

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE c-MYC regulates mRNA translation efficiency and start-site selection in lymphoma. 31142587

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Lastly, high-intensity chemotherapy (either dose-adjusted rituximab and etoposide-prednisone-vincristine-cyclophosphamide-doxorubicin or rituximab and hyperfractionated cyclophosphamide-vincristine-doxorubicin-dexamethasone treatment) did not improve survival in patients with MYC-EC and MYC-rearranged lymphoma when compared with rituximab-cyclophosphamide-hydroxydaunomycin-vincristine-prednisone therapy. 30496802

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE However, APE1 is unexpectedly dispensable for SHM in the S region and translocation between immunoglobulin heavy chain (IgH) and c-myc genes in the mouse B lymphoma cell line, CH12F3-2A. 30877298

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE Double-hit lymphoma (DHL) is defined as lymphoma with concurrent BCL2 and MYC translocations. 29310838

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Loss of one allele of KAT6A extends the median survival of mice with MYC-induced lymphoma from 105 to 413 days<sup>11</sup>. 30069049

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE The phosphatidylinositol 3 kinase (PI3K)-glycogen synthase kinase β (GSK3β) axis plays a central role in MYC-driven lymphomagenesis, and MYC targeting with bromodomain and extraterminal protein family inhibitors (BETi) is a promising treatment strategy in lymphoma. 30134175

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE There were 47 DTHLs, 36 cases with MYC and BCL2 and/or BCL6 extra signals (ES) and/or rearrangements (ES group, excludes DTHLs), 9 with MYC rearrangements only (single-hit lymphoma), and 95 with no MYC abnormalities (NM). 28614202

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma. 27717585

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Thirty-four MYC-R lymphoma cases were studied: 21 treated with R-CHOP and 13 treated with BURKIMAB. 28648593

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE Real-time polymerase chain reaction showed C-MYC mRNA expression in lymphoma-type and acute-type samples were significantly higher than in smoldering-type (P<0.01). 28498285

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE The latest revision of lymphoma's World Health Organization classification describes the new provisional entity "Burkitt-like lymphoma with 11q aberration" (BLL, 11q) as lacking MYC rearrangement, but harboring the specific11q-gain/loss aberration. 29272887

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE In B-lymphoma cells, as a consequence of PCYT1A upregulation, MYC impeded lymphoma cells undergo a mitophagy-dependent necroptosis. 28686226

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE Dual-expressor lymphoma is a form of DLBCL with overexpression of MYC and BCL2/BCL6. 28952038

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE In total, 76 patients with diffuse large B-cell lymphoma had MYC extra copies including 43 cases of double or triple extra copy lymphoma; 105 patients had diffuse large B-cell lymphoma with MYC-R including 56 double- or triple-hit lymphoma; and 482 diffuse large B-cell lymphoma patients had no MYC abnormality (MYC normal). 28776574

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE Most of the refractory patients exhibit double-hit lymphoma (MYC-BCL2 rearrangement) or double-protein-expression lymphoma (MYC-BCL2 hyperexpression) which have a more aggressive clinical picture. 27913503

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Here, we demonstrate that coordinated targeting of rDNA transcription and PI3K-AKT-mTORC1-dependent ribosome biogenesis and protein synthesis provides a remarkable improvement in survival in MYC-driven B lymphoma. 26490423

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE Here, we report that the Zn(2+)-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. 26832406

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE MYC translocations occurred as single hit (only MYC rearranged, 63%) or multiple hit lymphoma (37%) and presented as acute leukemia (AL) (14%), Burkitt lymphoma (30%), chronic lymphocytic leukemia (CLL) (21%) or other mature B-cell neoplasms (35%). 27810071

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE In our patient series, we confirm the dismal prognosis of MYC+ lymphoma patients. 26820684

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Oncogene MYC is deregulated in many human cancers, especially in lymphoma. 25692307

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE In contrast, Burkitt leukemia/lymphoma is a mature B lymphocyte neoplasm with a characteristic germinal center immunophenotype and MYC rearrangement. 26489677

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression BEFREE Patients with both MYC and BCL2 CNA had similar outcomes to those with classic double hit lymphoma or protein double expression lymphoma (MYC and BCL2/BCL6 coexpression). 26158410

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE We identify lymphoma subtype-specific enhancers in the MYC locus that are silenced in lymphomas with MYC-activating rearrangements and are associated with germline polymorphisms that alter lymphoma risk. 26229090

2015