Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE The aim of this article is to provide consensus opinion from experts in the fields of hematopoietic cell transplantation, cellular immunotherapy, and lymphoma regarding key clinical questions pertinent to the use of CD19 CAR T cell products for the treatment of NHL. 31446199

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation BEFREE Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19. 31439577

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE In this regard, CD19-specific CAR T cell therapies have achieved dramatic objective responses for a high percent of patients with CD19-positive leukemia or lymphoma. 30828333

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. 31429760

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE We conducted a clinical trial to assess the safety and efficacy of CD19-targeting CAR-T-cells in the treatment of relapsed and chemotherapy-refractory B-ALL and lymphoma. 30198955

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CD19 chimeric antigen receptor-T cells in B-cell leukemia and lymphoma: current status and perspectives. 31690821

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CD19-targeted CAR-T is an effective modality in treating refractory B-cell malignancies including leukemia and lymphoma. 28762313

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Tisagenlecleucel (kymriah, Novartis) is an autologous CD19-targeted CAR T cell product approved for treatment of R/R B cell ALL and lymphoma. 30764841

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CD19 Chimeric antigen receptor (CAR) T cell therapy has been shown to be effective for B cell leukemia and lymphoma. 31847470

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CAR-expressing T cells against CD19 can cause curative effects in leukemia and lymphoma and is approved for clinical use. 30622115

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CAR T cells have revolutionized the treatment of relapsed and refractory CD19-positive leukemia and lymphoma. 30680777

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CD19 chimeric antigen receptor (CAR) T cell therapy has changed the outcomes of relapsed/refractory B‑cell leukemia and lymphoma. 30942469

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Autologous T cells transduced with CD19-directed chimeric antigen receptors have recently been approved by several regulatory agencies for the treatment of relapsed and refractory leukemia and lymphoma, after demonstrating remarkable remission rate in advanced patients. 30809033

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Decitabine enhances cytotoxic effect of T cells with an anti-CD19 chimeric antigen receptor in treatment of lymphoma. 31372000

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. 31611950

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE T cell immunotherapies are promising options in leukemia, among which the CD19/CD3-bispecific T cell engager antibody blinatumomab (MT103) has shown high response rates at very low doses in patients with lymphoma. 30611570

2019

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE The remarkable clinical response rates achieved by adoptive transfer of T cells that target CD19 in patients with leukemia and lymphoma have led to a growing number of clinical trials exploring CAR T-cell therapy for solid tumors. 29107016

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE In order to treat lymphoma, monoclonal antibodies (mAb) can target different antigens, including CD19, CD20 and CD22 on the surface of B-cells. 29922424

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CD-19 CAR-T cells have been recently approved for high-risk R/R ALL and lymphoma. 29544528

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE Early trials with anti-CD19 CAR T cells have achieved spectacular remissions in B-cell leukemia and lymphoma, so far refractory, very recently resulting in the Food and Drug Administration approval of CD19 CAR T cells for therapy. 29620951

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia. 30097433

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE The Food and Drug Administration has approved CAR T cells that target CD19 for treatment of advanced B cell leukemia and lymphoma. 29685162

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE CD19 CAR T Cells Expressing IL-12 Eradicate Lymphoma in Fully Lymphoreplete Mice through Induction of Host Immunity. 29367945

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE In CAR T cell therapy targeting CD19 for lymphoma, host immune anti-murine CAR responses limited the efficacy of repeat dosing and possibly long-term persistence. 29678657

2018

Entrez Id: 930
Gene Symbol: CD19
CD19
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker BEFREE These data suggest that Igβ and CD19 are part of an alternative B-cell signaling module that use continuous ITAM/PI3K signaling to promote the survival of B lymphoma and normal B cells. 29669863

2018