Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE Detection of PIK3CA Mutations in Plasma DNA of Colorectal Cancer Patients by an Ultra-Sensitive PNA-Mediated PCR. 28247181

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 AlteredExpression BEFREE NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway. 28418896

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2. 27913571

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer. 29260353

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 AlteredExpression BEFREE These results implied that B7-H3 can induce colorectal cancer cell resistance to 5-FU by increasing TS expression and PI3K/Akt/TS signaling and plays an important role during these processes. 26787540

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE This approach classified CRC into two major groups consistent with previous classification systems: (1) ∼16 % hypermutated cancers with either microsatellite instability (MSI) due to defective mismatch repair (∼13 %) or ultramutated cancers with DNA polymerase epsilon proofreading mutations (∼3 %); and (2) ∼84 % non-hypermutated, microsatellite stable (MSS) cancers with a high frequency of DNA somatic copy number alterations, which showed common mutations in APC, TP53, KRAS, SMAD4, and PIK3CA. 27325016

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Together, these results suggest that PIK3CA and PIK3CB may be used as potential therapeutic drug targets for colorectal cancer. 26747178

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 AlteredExpression BEFREE Silencing of COL3A1 suppressed CRC cell proliferation in in vitro MTT assay and in in vivo Zebra fish xenograft model by downregulation of PI3K/AKT and WNT signaling. 26741506

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells. 28154202

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer. 27511117

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE Several recent studies have reported an improvement in overall survival in colorectal cancer patients who harbored mutations in the oncogene PIK3CA and received a daily aspirin regimen. 26915040

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway. 26847718

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. 26238857

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE PIK3CA Somatic Mutation Status in Relation to Patient and Tumor Factors in Racial/Ethnic Minorities with Colorectal Cancer. 25994739

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE PIK3CA and BRAF were exhibited by 5 and 4 of the patients with CRC.TP53 mutants exhibited higher SUV(max). 26018692

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE BKM120 targets phosphatidylinositide-3-kinase (PIK3CA), but it is unknown whether BKM120 can reverse cetuximab resistance in KRAS mutant CRC. 26715098

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE Commonly observed alterations across sporadic CRCs have allowed classification into a (1) hypermutated group that includes defective DNA mismatch repair with microsatellite instability and POLE mutations in ∼15%, containing multiple frameshifted genes and BRAF(V600E); (2) nonhypermutated group with multiple somatic copy number alterations and aneuploidy in ∼85%, containing oncogenic activation of KRAS and PIK3CA and mutation and loss of heterozygosity of tumor suppressor genes, such as APC and TP53; (3) CpG island methylator phenotype CRCs in ∼20% that overlap greatly with microsatellite instability CRCs and some nonhypermutated CRCs; and (4) elevated microsatellite alterations at selected tetranucleotide repeats in ∼60% that associates with metastatic behavior in both hypermutated and nonhypermutated groups. 26216840

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers. 26404261

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. 26224873

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE These findings indicate that KRAS and PIK3CA mutations can influence the response of DLD1 colorectal cancer cell lines to MEK and PI3K inhibitors, but that the effect is dependent on the experimental model used to assess drug sensitivity. 26820797

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Mutations in KRAS, BRAF, and PIK3CA were found in 104 (54.5%), 6 (3.1%), and 25 (13.1%) cases of advanced CRC, respectively. 26991109

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation. 26955235

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker BEFREE MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. 26718987

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE However, no association was detected between rs2699887 in the PIK3CA gene and CRC risk. 26722535

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation BEFREE Mutations of mismatch repair genes, e.g., MSH3 and MSH6, and genes in PI3K, WNT, TGF-β and BMP signaling (but not in TP53 signaling) were significantly involved in high-methylation CRC compared with adenoma, suggesting importance of abrogation of these genes in serrated pathway. 26510091

2016