×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
GeneticVariation
BEFREE
Advanced-stage HCC (BCLC B/C) showed higher frequencies of splicing factor 3b subunit 1 (SF3B1) (P = 0.0003), TP53 (P = 0.0006), and RB Transcriptional Corepressor 1 mutations (P = 0.03).
31206197 2020
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
GeneticVariation
BEFREE
Altogether, 40% of the HCC specimens (16/40) showed hyper- or hypomethylation at the CpG island in intron 2 of the RB1 gene.
24838394 2014
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
Biomarker
BEFREE
Cell cycle control involving RB1 gene-related cell inhibitors is one of the main regulatory pathways were reported to be altered in hepatocellular carcinoma (HCC ).
24254306 2014
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
Biomarker
BEFREE
Two of the 26 HCC and one of the 9 HB showed >10% tumour nuclear staining for pRb protein.
24935581 2014
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
AlteredExpression
BEFREE
Key mechanisms underlying the effect of PPARγ in HCC include upregulation of cell adhesion genes, E-cadherin and SYK (spleen tyrosine kinase), extracellular matrix regulator tissue inhibitors of metalloproteinase (TIMP) 3, tumour suppressor gene retinoblastoma 1 , and downregulation of pro-metastatic genes MMP9 (matrix metallopeptidase 9), MMP13, HPSE (heparanase), and Hepatocyte growth factor (HGF).
22472882 2012
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
PosttranslationalModification
LHGDN
Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells.
16254459 2005
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
PosttranslationalModification
BEFREE
All 24 HCC s with RB1 promoter methylation lacked RB1 expression, while none of the 67 cases with RB1 expression exhibited RB1 methylation (p < 0.0001), suggesting that promoter methylation is a major mechanism of loss of RB1 expression in HCC s.
12845670 2003
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
Biomarker
BEFREE
We investigated p14(ARF), p15(INK4B), p16(INK4A), p18(INK4C), and RB1 genes in a series of HCC s and associated cirrhosis with the goal of ascertaining their pattern of inactivation by gene methylation.
12143052 2002
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
Biomarker
CTD_human
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis.
12029619 2002
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
Biomarker
CTD_human
Retinoblastoma gene mutations in chemically induced liver tumor samples of Japanese medaka (Oryzias latipes).
14961299 2001
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
GeneticVariation
BEFREE
These findings are applicable to HCC with abberrations of both p53 and pRb genes, and may not represent the universal effects of p53 in hepatic cells.
10952243 2000
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
GeneticVariation
BEFREE
Allelic alteration of the Rb-1 gene was observed in two cases, deletion of both alleles in the hepatocellular carcinoma component of case 3 (combined type) and replication error of the same pattern in both components of case 4 (mixed type).
8957064 1996
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Liver carcinoma
0.400
GeneticVariation
BEFREE
Deletions of chromosome 13q, mutations in Retinoblastoma 1 , and retinoblastoma protein state in human hepatocellular carcinoma .
8033150 1994