|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Protective role of HLA-DRB1*11 against juvenile idiopathic arthritis living in North Eastern Iran.
|
29942445 |
2018 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
|
28182665 |
2017 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles and juvenile idiopathic arthritis: Diagnostic clues emerging from a meta-analysis.
|
29037901 |
2017 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Association of HLA-A*02:06 and HLA-DRB1*04:05 with clinical subtypes of juvenile idiopathic arthritis.
|
21179106 |
2011 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans.
|
20346252 |
2010 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients.
|
19210888 |
2009 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Association of HLA-DRB1*13 with susceptibility to uveitis in juvenile idiopathic arthritis in two independent data sets.
|
16495319 |
2006 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1 genotyping in patients with juvenile idiopathic arthritis in Taiwan.
|
15265024 |
2004 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1 alleles of these two haplotypes share the epitope (70)DRRAA(74)and were associated with both the pauciarticular and the systemic subset of JRA.
|
15120191 |
2004 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of MHC region genetics in Finnish patients with juvenile idiopathic arthritis: evidence for different locus-specific effects in polyarticular vs pauciarticular subsets and a shared DRB1 epitope.
|
12847547 |
2003 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
DRB1*0308 was only detected in children with oligoarticular JRA, none of the children with polyarticular JRA or the controls had this allele.
|
12846065 |
2003 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
The frequency of DRB1*03 was found to be much higher in the polyarticular subtype of Kuwaiti JRA cases compared to the oligoarticular subgroup and the controls.
|
11841481 |
2002 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
A common HLA-DRB1* allele was not involved in the JCA groups and subgroups studied; on the other hand, the DQA1*0501 allele was found to be associated with different JCA groups/subgroups (O-JCA, P-JCA RF-negative ANA-positive, JCA with CAU), probably suggesting a closer relationship of this locus with the immunogenetic background of JCA.
|
10457895 |
1999 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The -857T allele may enhance the effect of the DRB1*0405/DQB1*0401 haplotype in predisposing to development of systemic JRA.
|
10616003 |
1999 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Comparisons among patients with RA, patients with RF positive polyarticular JRA, and controls showed increased frequencies of the RA shared epitope in patients with RA and of DRB1*0901 in patients with seropositive polyarticular JRA, while the frequency of DRB1*08 alleles was decreased in patients with RF positive polyarticular JRA.
|
9858424 |
1998 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Stratification of the EOPA-JCA group into antinuclear antibody (ANA) positive (n = 18) and ANA negative (n = 25) individuals revealed that ANA positivity was only associated with DRB1*1301 (OR 4.2, 95% CI 1.0-17.3), DPB1*0201 (OR 4.0, 95% CI 1.0-15.7) and DQB1*0603 (OR 11.5, 95% CI 2.5-53.4).
|
7788177 |
1995 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Certain HLA associations (DRB1*0801, DPB1*0201) appear to be present in patients with JA in most studies; others (DRB1*1301, DPB1*0301) are more variable.
|
8151573 |
1994 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*04 and TAP2D were found to be in linkage disequilibrium in both the control (delta 0.018 p < 0.05) and JCA patient groups (delta 0.021 p < 0.05).
|
8203956 |
1994 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis.
|
8102807 |
1993 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
However, when the JRA patients were classified into four clinical types, i.e., a rheumatoid factor-positive [RF(+)] polyarticular type, a rheumatoid factor-negative [RF(-)] polyarticular type, a pauciarticular type, and a systemic onset type, DRB1*0405 was found to be significantly higher in the RF(+) polyarticular JRA patients than in the controls (P < 0.05).
|
8356392 |
1993 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease.
|
8457222 |
1993 |
|
HLA-DRB1
|
Juvenile rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Eighty-six percent of our patients present either HLA-DR5 or the beta DR-2.9-kb-EcoRI allogenotope or lack the C4-14.3-kb-EcoRI allogenotope compared to 48% in controls; however, these particular DR and C4 RFLPs may not represent the corresponding DRB1 or C4 genes but rather neighboring ones which may be relevant to confer JRA susceptibility.
|
1972672 |
1990 |