|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 shared epitope (SE) alleles were detected in patients with RA.
|
24817415 |
2015 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis.
|
20383728 |
2010 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
One hundred and eight patients with early RA (85 female, 23 male) who visited our clinic within 1 year of symptom onset were examined for anti-GPI and anti-CCP Ab levels, and HLA-DRB1 genotype.
|
19032829 |
2009 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide.
|
17543145 |
2007 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study.
|
17469097 |
2007 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 genotypes were evaluated in 123 patients with early RA (98 female, 25 male) within 1 year of symptom onset.
|
17876645 |
2007 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
|
16385499 |
2006 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept.
|
15457442 |
2004 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Patients expressing the RA-associated shared epitope (SE) on a DRB1*01-positive or, most prominently, on a DRB1*04-positive allele had higher Larsen scores at all time-points analysed when compared with SE-negative patients.
|
12649403 |
2003 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
To study the impacts of 1) the delay from the onset of symptoms to the institution of disease-modifying antirheumatic drug (DMARD) therapy, 2) two treatment strategies (treatment with a combination of DMARDs or with a single drug), and 3) the presence of HLA-DRB1 alleles (shared epitope) on the prediction of disease remission after 2 years in patients with early rheumatoid arthritis (RA).
|
11953964 |
2002 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
By univariate analysis with Fisher's exact test, radiologic scores and progression at followup were closely correlated with the baseline values of the erythrocyte sedimentation rate (ESR), C-reactive protein level, IgM and IgA rheumatoid factor positivity, antiperinuclear antibody positivity, radiologic scores, duration of morning stiffness, and RA-associated HLA-DRB1*04 genes.
|
11508423 |
2001 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
DRB1 alleles encoding a DERAA motif in their third hypervariable region provided a strong dominant protection against RA among DQ5-positive individuals and decreased arthritis activity among DQ3-positive patients.
|
11257148 |
2001 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1 genes, rheumatoid factor, and elevated C-reactive protein: independent risk factors of radiographic progression in early rheumatoid arthritis. Berlin Collaborating Rheumatological Study Group.
|
10990219 |
2000 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
There are conflicting data concerning the role of HLA-DRB1 alleles in disease outcome in early rheumatoid arthritis.
|
10524690 |
1999 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Lack of association of HLA-DRB1 genotype with radiologic progression in Japanese patients with early rheumatoid arthritis.
|
9416863 |
1997 |
|
HLA-DRB1
|
Early Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
HLA-DRB1*04 subtypes are associated with increased inflammatory activity in early rheumatoid arthritis.
|
9376988 |
1997 |