Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 AlteredExpression BEFREE Upregulation of BMI-1 has been reported in MCL patients, especially in those with refractory/relapsed disease. 29983879

2018
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 AlteredExpression BEFREE These results suggest that upregulation of BMI1 and downregulation of miR-16 in MCL SP has a key role in the disease's progression by reducing MCL cell apoptosis. 23686310

2014
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 GeneticVariation BEFREE These findings point to genomic instability at the 10p region in MCL which likely promotes rearrangements and deregulation of BMI1. 23873701

2013
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 AlteredExpression BEFREE BMI-1 protein expression is deregulated in several forms of cancer and gene amplification has been identified in mantle cell lymphomas. 18427816

2008
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 AlteredExpression BEFREE In particular, Cyclin D1 upregulation, genomic amplification of the cyclin-dependent kinase (CDK) -4, deletions of the CDK inhibitor p16(INK4a) and overexpression of BMI-1, a transcriptional repressor of the p16(INK4a) locus, are associated with dysregulation of the cell cycle machinery in MCL. 16155021

2005
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 GeneticVariation BEFREE The four tumors with gene amplification showed significantly higher mRNA levels than other MCLs and NHLs with the BMI-1 gene in germline configuration. 11289106

2001
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.070 AlteredExpression BEFREE Also, BMI1 and RING1 continued to be expressed in proliferating MCL. 11298590

2001