×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
AlteredExpression
BEFREE
However, the mechanism by which miR-145 contributes to regulate PD-L1 expression in cisplatin-resistance of ovarian cancer is yet to be fully understood.
31821542
2020
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
AlteredExpression
BEFREE
Subgroup analysis based on tumor type showed that the downregulation of miR-145 was associated with unfavorable OS in colorectal cancer (HR = 2.17; 95% CI, 1.52-3.08; <i>P</i> < 0.001), ovarian cancer (HR = 2.15; 95% CI, 1.29-3.59; <i>P</i> = 0.003), gastric cancer (HR = 1.78; 95% CI, 1.35-2.36; <i>P</i> < 0.001), glioma (HR = 1.65; 95% CI, 1.30-2.10; <i>P</i> < 0.001), and osteosarcoma (HR = 2.28; 95% CI, 1.50-3.47; <i>P</i> < 0.001).
30602498
2019
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
In conclusion, decreased expression of hsa‑miR‑145 in OC and OC ‑derived exosomes may be a crucial biomarker for the diagnosis and treatment of OC .
30365097
2019
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
CTD_human
Downregulation of miR-145 -5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT.
30365097
2019
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
Therefore, miR‑145 was suggested to be a potential miRNA‑based therapeutic target in ovarian cancer .
30864742
2019
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
Serum exosomal miR-145 in particular appeared to be the most promising biomarker for preoperative diagnosis of ovarian cancer .
31205555
2019
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
In conclusion, a feedback loop between miR-145 and DNMT3A is a potent signature for the Warburg effect in ovarian cancer , promising a potential target for improved anticancer treatment.
29993160
2018
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
Mechanisms of miR-145 regulating invasion and metastasis of ovarian carcinoma .
28804560
2017
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
The results from nude mouse xenograft models further demonstrate the suppressive effect of miR-145 on malignant progression of ovarian cancer .
28881818
2017
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
AlteredExpression
BEFREE
miR-145 expression was downregulated in EOC tissues and cell lines as compared with normal ovarian tissues.
26472353
2015
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
Low miR-145 and high HMGA2 expressions are potential biomarkers of poor prognosis of ovarian carcinoma and miR-145 is the more powerful predictor of patient outcome.
25444913
2015
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
Biomarker
BEFREE
Therefore, the result indicated that miR- 145 could be used as a potential therapeutic target in ovarian cancer .
23919393
2014
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
AlteredExpression
BEFREE
In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer , compared to healthy ovarian tissues, cell lines and serum samples.
24157791
2013
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
Carcinoma, Ovarian Epithelial
0.400
AlteredExpression
BEFREE
The loss of miR-145 can result in the activation of factors that promote oncogenesis and cellular pluripotency which in turn could lead to the development of ovarian cancer .
22285623
2012