Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis. 30983885

2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Overexpression of long non coding RNA CA3-AS1 suppresses proliferation, invasion and promotes apoptosis via miRNA-93/PTEN axis in colorectal cancer. 30415006

2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog. 30186399

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A. 30118842

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE High expression of DJ-1 promotes growth and invasion via the PTEN-AKT pathway and predicts a poor prognosis in colorectal cancer. 29441725

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway. 30064475

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE Our data demonstrated that suppression of miR-29a enhanced PTEN expression, inhibited cancer cell proliferation, facilitated apoptosis, and weakened drug resistance, which provides academic basis for the treatment of colorectal cancer. 30229821

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Our present results implicate the newly indentified miR-22/Sp1/PTEN/AKT axis might represent a potential therapeutic target for colorectal cancer. 28422727

2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Involvement of miR-155/FOXO3a and miR-222/PTEN in acquired radioresistance of colorectal cancer cell line. 28879560

2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer. 28957811

2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN. 28779166

2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE NHERF1/EBP50, an adaptor molecule that interacts with β-catenin, YAP, and PTEN, has been recently implicated in the progression of various human malignancies, including colorectal cancer. 27566107

2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) loss of function is frequently detected in advanced colorectal cancer. 27392434

2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. 26224641

2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway. 25515201

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer. 26098881

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer. 25986931

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. 26238857

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases. 25639985

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE PTEN is a downstream inhibitor of the EGFR pathway and has been evaluated as a predictive factor of cetuximab efficacy in colorectal cancer. 24595598

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17. 24218517

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 GeneticVariation BEFREE The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population. 24935469

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 GeneticVariation BEFREE Mutational and expressional analyses of PTEN gene in colorectal cancer from Northern India. 23359334

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE These findings suggest that miR-20b, -21, and -130b, up-regulated in colorectal cancer, through inhibiting the expression of PTEN, result in B7-H1 over-expression in colorectal cancer. 24468585

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE These results suggest that PTEN may play important roles in colorectal cancer cell proliferation and migration. 25272061

2014