We sought to: a) synthesize the available evidence on potential differences between AN patients and controls with regards to adipokine measurements (namely, leptin, adiponectin, resistin, soluble leptin receptor, visfatin, vaspin and omentin), b) estimate the potential differences between constitutionally thin (CT) subjects and AN patients, and c) present the available evidence with regards to biomarker efficacy of adipokines in AN.
First, <i>LEP</i> and <i>LEPR</i> methylation at baseline were lower in patients compared to controls (<i>LEP</i>: [%] AN: 30.94 ± 13.2 vs. controls: 34.53 ± 14.6); LEPR ([%] AN: 3.73 ± 5.4 vs. controls: 5.22 ± 8.3, mixed linear models: both <i>P</i> < 0.001).
In the present study, SNPs in the coding region of the leptin receptor were analysed and their possible association with anorexia nervosa was investigated.