Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 AlteredExpression BEFREE Tissue samples of colon cancer from 148 patients who underwent colon resection due to colon cancer were analyzed by immunohistochemical staining to determine the protein expression levels of S100A4. 30111999

2018
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 Biomarker BEFREE Previous studies have shown that IL-1β promotes the stemness of colon cancer cells, and S100A4 is also involved in maintaining cancer-initiating cells in head and neck cancers. 29932233

2018
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 Biomarker BEFREE Mice intrasplenically transplanted with S100A4-overexpressing colon cancer cells were treated with sulindac. 21403839

2011
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 Biomarker BEFREE S100A4, a calcium-binding protein, is implicated in promoting metastasis formation in colon cancer. 21685359

2011
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 Biomarker BEFREE S100A4 is a target gene of the Wnt/β-catenin pathway, which is constitutively active in the majority of colon cancers. 21795396

2011
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 Biomarker BEFREE We found that S100A4 is induced in a subset of colon cancer cell lines, and the ability to induce S100A4 depends on the methylation status of S100A4. 21289293

2011
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 AlteredExpression BEFREE S100A4 overexpression decreases the sensitivity of HT29 colon cancer human cells to MTX, whereas its knockdown causes chemosensitization toward MTX. 20515499

2010
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.380 Biomarker BEFREE Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors. 17101323

2006