Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Anti-epidermal growth factor receptor-targeted therapy is only indicated in RAS wild-type colorectal carcinomas (CRCs). 26862952

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with <i>BRAF</i> or <i>KRAS</i> Mutations. 28611205

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Evaluation of the RAS mutation status is necessary for patients with advanced colorectal cancer to predict the response to anti-EGFR therapy. 28551386

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. 28945877

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Genetic variability in KRAS and EGFR predicts response to cetuximab in irinotecan refractory colorectal cancer. 28025786

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer. 28698359

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE RHBDD1 upregulates EGFR via the AP-1 pathway in colorectal cancer. 28445956

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE HER2 as an Emerging Oncotarget for Colorectal Cancer Treatment After Failure of Anti-Epidermal Growth Factor Receptor Therapy. 28363756

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Preclinical evidence suggests that concomitant BRAF and EGFR inhibition leads to sustained suppression of MAPK signaling and suppressed tumor growth in <i>BRAF</i><sup>V600E</sup> colorectal cancer models. 28363909

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Activating KRAS mutations drive colorectal cancer tumorigenesis and influence response to anti-EGFR-targeted therapy. 28173629

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE MEK activation, by different genetic mechanisms, has been described for both intrinsic and acquired resistance to drugs targeting the EGFR (Epidermal Growth Factor Receptor)-RAS-RAF pathway in CRC, NSCLC. 28073102

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE EZH2 expression is a prognostic biomarker in patients with colorectal cancer treated with anti-EGFR therapeutics. 28147317

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells. 26386720

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer. 28199979

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Biomarkers of skin toxicity induced by anti-epidermal growth factor receptor antibody treatment in colorectal cancer. 26811634

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE In this review, we systemically summarize the roles of miRNAs as regulators, tissue or circulating biomarkers, and therapeutics in the CRC resistance to 5-fluorouracil (5-FU), oxaliplatin and anti-EGFR therapy. 27842308

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features. 28936923

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE A Novel Role for MiR-520a-3p in Regulating EGFR Expression in Colorectal Cancer. 28738328

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE In clinic, cetuximab, an anti-EGFR antibody, improves treatment outcomes in colorectal cancer (CRC). 28301591

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death. 28823963

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE - To develop evidence-based guideline recommendations through a systematic review of the literature to establish standard molecular biomarker testing of colorectal cancer (CRC) tissues to guide epidermal growth factor receptor (EGFR) therapies and conventional chemotherapy regimens. 28165284

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients. 28400195

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Response to epidermal growth factor receptor inhibitors is poorer among stage IV colorectal cancer (CRC) patients with KRAS mutations; thus KRAS testing is recommended before treatment. 25844824

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE To develop evidence-based guideline recommendations through a systematic review of the literature to establish standard molecular biomarker testing of colorectal cancer (CRC) tissues to guide epidermal growth factor receptor (EGFR) therapies and conventional chemotherapy regimens. 28185757

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Somatic mutations in KRAS, NRAS, and BRAF genes are related to resistance to anti-EGFR antibodies in colorectal cancer. 25954997

2016