Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Rs5219 at KCNJ11 (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population. 27253191

2017

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Our calculations identified causal genetic variation within the ABCC8/KCNJ11 region for T2DM with an OR of approximately 1.15 in Caucasians and Asians. 25955821

2016

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE Our findings provided evidence that KCNJ11 was associated with DR in Chinese Han patients with T2DM. 25573672

2016

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes. 26315042

2016

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The E23K and A190A variations of the KCNJ11 gene are associated with early-onset type 2 diabetes and blood pressure in the Chinese population. 25725792

2016

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians. 25755232

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The findings of the present study suggest that the KCNJ11 E23K variant is associated with a greater effect of sulphonylurea treatment in newly diagnosed Chinese patients with T2DM. 25115353

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis. 25165692

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Lack of genetic susceptibility of KCNJ11 E23K polymorphism with risk of type 2 diabetes in an Iranian population. 24460047

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study. 25247988

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Among women with magnesium intake in the lowest 30% (AA: ≤0.164 g/d; HA: ≤0.185 g/d), 4 SNP signals were strengthened [rs11590362 in claudin 19 (CLDN19), rs823154 in SLC41A1, rs5929706 and rs5930817 in membra; HA: ≥0.313 g/d), rs6584273 in CNNM1 (OR: 0.71; FDR-adjusted P = 0.04) and rs1800467 in potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) (OR: 2.50; FDR-adjusted P = 0.01) were significantly associated with T2D risk. 25733456

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE E23K variant in KCNJ11 gene is associated with susceptibility to type 2 diabetes in the Mauritanian population. 24332549

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes. 24710510

2015

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Sib-TDT analysis showed that some gene variants were significantly associated with T2D risk but didn't reach the level of significance after Bonferroni correction [KCNJ11 (rs5219), p=0.047] and [CAPN10 (rs41266971), p=0.035]. 24993573

2014

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. 24018988

2014

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE We observed consistent and significant associations of IGF2BP2, WFS1, CDKAL1, SLC30A8, CDKN2A/B, HHEX, TCF7L2 and KCNQ1 (8.5×10(-18)<P<8.5×10(-3)), as well as nominal associations of NOTCH2, JAZF1, KCNJ11 and HNF1B (0.05<P<0.1) with T2D risk, which yielded odds ratios ranging from 1.07 to 2.09. 24376643

2014

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE IGF2BP2 [P = 1.3 × 10(-5); OR (95% CI): 1.66 (1.42-1.94)] and PPARγ [P = 0.005; OR (95% CI): 1.41 (1.10-1.80)] were associated with T2DM in the Lebanese, but not Tunisians, while KCNJ11 [P = 8.0 × 10(-4); OR (95% CI): 1.27 (1.09-1.47)] and SLC30A8 [P = 1.6 × 10(-5); OR (95% CI): 1.37 (1.15-1.62)] were associated with T2DM in the Tunisians, but not Lebanese, after adjusting for gender and body mass index. 22749234

2013

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11. 22569928

2013

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The KCNJ11 E23K gene polymorphism and type 2 diabetes mellitus in the Chinese Han population: a meta-analysis of 6,109 subjects. 23054005

2013

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. 22264780

2012

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable haplotype that is associated with an increased susceptibility to type 2 diabetes (T2D) risk. 22187380

2012

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. 22163043

2012

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals. 21573802

2012

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The common ATP-sensitive potassium (KATP) channel variants E23K and S1369A, found in the KCNJ11 and ABCC8 genes, respectively, form a haplotype that is associated with an increased risk for type 2 diabetes. 22209866

2012