Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Our study suggests that Glu298Asp single nucleotide polymorphism of the eNOS gene may be an independent risk factor for hypogonadism-associated type 2 DM. 25228279

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease. 25077953

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association between a 27-bp variable number of tandem repeat polymorphism in intron 4 of the eNOS gene and risk for diabetic retinopathy Type 2 diabetes mellitus: a meta-analysis. 24673412

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, we have described for the first time a significant correlation of statin treatment and CYP3A4 2 and eNOS gene polymorphisms in T2D, suggesting a new genetic susceptibility factor for insulin resistance and hyperlipidemia in T2D. 24996290

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of endothelial nitric oxide synthase gene polymorphisms with type 2 diabetes mellitus: a meta-analysis. 23563728

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Interaction between the NOS3 gene and obesity as a determinant of risk of type 2 diabetes: the Atherosclerosis Risk in Communities study. 24278136

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. 23182401

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus. 23157875

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In view of the variable results that have been reported for the association between eNOS gene polymorphisms and DR, the present study was designed to study the association and interaction between eNOS gene polymorphisms and the development and progression of DR in Asian Indian type 2 diabetes mellitus patients (T2DM). 23085930

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The 4a/4a genotype of the VNTR polymorphism for endothelial nitric oxide synthase (eNOS) gene predicts risk for proliferative diabetic retinopathy in Slovenian patients (Caucasians) with type 2 diabetes mellitus. 22311033

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Relationship of endothelial nitric oxide synthase (eNOS) gene polymorphisms with diabetic retinopathy in Caucasians with type 2 diabetes. 22017289

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase gene polymorphism (G894T) and diabetes mellitus (type II) among South Indians. 22110783

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus. 22313046

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Since NO availability may be genetically determined, we have investigated the role of endothelial nitric oxide synthase (eNOS) gene in influencing platelet aggregability in relation to the presence (n=247) or absence (n=883) of type 2 diabetes in ACS patients. 19819117

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of eNOS gene polymorphisms with renal disease in Caucasians with type 2 diabetes. 21255858

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with type 2 diabetes and its chronic complications. 21256614

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus. 19077211

2009

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Intron 4 a/b polymorphism of the endothelial nitric oxide synthase gene is associated with both type 1 and type 2 diabetes in a genetically homogeneous population. 18486763

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We evaluated the association of -786T>C (promoter region), Glu298Asp (Exon 7), and 4b4a (Intron 4) polymorphisms in eNOS gene with Type 2 diabetes mellitus (T2DM) and DN by haplotype analysis. 18413207

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans. 18537098

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE To address this issue, we investigated the potential association between polymorphisms of the eNOS gene and diabetes-related phenotypes in 384 persons with type 2 diabetes and 191 controls from two West African countries (Ghana and Nigeria). 18079690

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. 18622262

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The aim of the present study was to examine the role of the V16A polymorphism of the Mn-SOD gene and the 4a/b polymorphism of the eNOS gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes. 18057537

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. 18069999

2008