Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8877
Gene Symbol: SPHK1
SPHK1
CUI: C0017638
Disease: Glioma
Glioma 		0.240 Biomarker BEFREE Similarly, downregulation of SphKs by siRNA inhibited glioma cell proliferation, and the cell cycle was arrested in G(2) /M phase when SphK1 was inhibited. 22288844

2012
Entrez Id: 8877
Gene Symbol: SPHK1
SPHK1
CUI: C0017638
Disease: Glioma
Glioma 		0.240 AlteredExpression BEFREE Treatment of glioma cell lines with EGF led to increased expression and activity of SphK1. 20938717

2011
Entrez Id: 8877
Gene Symbol: SPHK1
SPHK1
CUI: C0017638
Disease: Glioma
Glioma 		0.240 PosttranslationalModification BEFREE Collectively, our results indicate that regulation of the Akt/FOXO3a/Bim pathway may be a novel mechanism by which SPHK1 protects glioma cells from apoptosis, thereby involved in glioma tumorigenesis. 21625639

2011
Entrez Id: 8877
Gene Symbol: SPHK1
SPHK1
CUI: C0017638
Disease: Glioma
Glioma 		0.240 AlteredExpression BEFREE We found that SK1 overexpression in HEK cells or its down-regulation in glioma or breast cancer cells modulated extracellular S1P levels accordingly, which in turn increased or decreased both migration and tube formation in cocultured vascular or lymphatic endothelial cells. 20335228

2010