Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation BEFREE Overall, while chronic administration of the model CAR activator NaPB results in both hepatocellular adenoma and carcinoma in the low spontaneous liver tumour incidence C57BL/10 J mouse strain, only 40% of the liver tumours evaluated in this study had β-catenin mutations. 31836555

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Thus, mTORC1 inhibitors could be highly relevant in the treatment of liver tumors that are β-catenin mutated and GS positive. 30713111

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 PosttranslationalModification BEFREE This was confirmed by RT-qPCR of an independent cohort of CTNNB1-mutated HCC and the suppression of the LKB1-related profile upon β-catenin silencing of CTNNB1-mutated human hepatoma cell lines. 30566242

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE <i>RSPO2</i> gene rearrangement: a powerful driver of β-catenin activation in liver tumours. 30901310

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Here, we show that rhein induces β-catenin degradation in both hepatoma cell HepG2 and cervical cancer cell Hela. 29024409

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression BEFREE Using both human HCC collections and engineered mouse models of liver cancers with AXIN1 mutation or deletion, we defined a common signature of liver tumors mutated for AXIN1 and demonstrate that these tumors occur independently of the activation of the Wnt/β-catenin pathway. 29525529

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation. 27881216

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation BEFREE An identical CTNNB1 mutation was identified in the 1996 liver tumor together with a TERT promoter mutation showing that this hepatocellular carcinoma results from the malignant transformation of the initial β-catenin inflammatory adenoma. 27984126

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE These data established Wnt/β-catenin as a novel signal produced by infiltrating macrophages induced by steatosis that promotes growth of tumor progenitor cells, underlying the increased risk of liver tumor development in obese individuals. 28671671

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation BEFREE Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression. 27177928

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation BEFREE This work demonstrates the key oncogenic role of miR-34a in liver tumours with β-catenin gene mutations. 25792709

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Taken together, these data indicate that β-catenin creates a protumorigenic hepatic environment in part by indirectly activating Nrf2 and implicate oxidative stress as a possible driving force for a subset of β-catenin-driven liver tumors in children. 27734029

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation BEFREE We found that forced overexpression of SKP2, N-RasV12 or ΔN90-β-catenin alone as well as co-expression of SKP2 and ΔN90-β-catenin did not induce liver tumor development. 25537506

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression BEFREE In summary, a senescence-inducing program was found in hepatocytes with increased β-catenin levels and a positive selection of hepatocytes lacking p16(INK4a), by epigenetic silencing, drives the development of liver tumors in mice with reduced APC expression (Apc(580S) mice). 25270420

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo. 24089139

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE The cell proliferation was significantly inhibited (up to 95.11 %) by shRNA plus anti-cancer drugs, suggesting that GPC-3 gene should be a potential target for promoting hepatoma cell apoptosis and inhibiting metastasis through the Wnt/β-catenin and Hh singling pathways. 24633918

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid. 23822752

2013

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression BEFREE In agreement with transcription level, β-catenin and cyclin D1 proteins are also down-regulated in transient and stable ZNF191 knockdown L02 and hepatoma Hep3B cell lines. 22213192

2012

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression BEFREE Additionally, core protein increases and stabilizes β-catenin levels in hepatoma cell line Huh7 through inactivation of GSK-3β, which contributes to the up-regulation of downstream target genes, such as c-Myc, cyclin D1, WISP2 and CTGF. 22110662

2011

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression BEFREE In conclusion, activated β-catenin in single hepatocytes induces a gene expression pattern in hepatocytes which is similar to that of Ctnnb1-mutated mouse liver tumors, but is apparently not sufficient to induce increased cell proliferation. 21822615

2011

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors. 21324921

2011

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression BEFREE Moreover, our data suggest that CCND1 expression is not essential for liver tumor development induced by c-Met and beta-catenin. 19118010

2009

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Overexpression of Tbx3 is closely associated with the mutational status of beta-catenin in murine liver tumors induced by Myc as well as in human hepatocellular carcinomas and hepatoblastomas. 17283120

2007

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker BEFREE Our data indicate that beta-catenin can be considered a specific target for gene therapy in pediatric hepatic tumors with mutations and overexpression of this gene. 16465377

2006

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation BEFREE Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. 16314847

2006