Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway. 28895255

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype. 26447864

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response. 26867682

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The cancer cell fraction assessed by the panel of the three genes showed good correlation with that assessed by the TP53 mutant allele frequency in 13 GCs (r = 0.77). 25678126

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Molecular characteristics, including overexpression of p53 (P < 0.001), overexpression of HER-2 (P = 0.006), and MSI (P = 0.006), were less frequent in gastric cancer of younger patients. 26078567

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE S100A4 interacts with mutant p53 and affects gastric cancer MKN1 cell autophagy and differentiation. 26497012

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE In previous work, we reported that EZH2 depletion functionally induced cellular senescence in human gastric cancer cells with mutant p53. 26004298

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In this report, we constructed a multiple promoter expression cassette-based recombinant adenovirus coexpressing ING4 and PTEN (AdVING4/PTEN), assessed the combined effects of AdVING4/PTEN on gastric cancer using wild-type p53 AGS and SNU-1 human gastric cancer cell lines, and elucidated its underlying mechanisms. 26564429

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE TFF1 activates p53 through down-regulation of miR-504 in gastric cancer. 25015107

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The depletion of PARN arrested the gastric cancer cells at the G0/G1 phase by upregulating the expression levels of p53 and p21 but not p27. 25499764

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. 25697906

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Role of p53 in the progression of gastric cancer. 25427447

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE However, no overall association was found between the TP53 Arg72Pro polymorphism and gastric cancer risk. 25190020

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer. 25354498

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. 24841718

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The p53 pathway was inactivated by mutations of TP53 in 19 GCs and potentially by aberrant methylation of its downstream genes in 38 GCs. 24510342

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. 24740294

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells. 24738879

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. 24045667

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Ghrelin signaling promotes the oncogene CDK6 gene expression and represses the tumor suppressor gene P53 gene expression in gastric cancer. 23807739

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Mortalin is a prognostic factor of gastric cancer with normal p53 function. 23828548

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Furthermore, knockdown of MEG3 expression by siRNA could promote cell proliferation, while ectopic expression of MEG3 inhibited cell proliferation, promoted cell apoptosis, and modulated p53 expression in gastric cancer cell lines. 24006224

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE In conclusion, OSR1 acts as a functional tumour suppressor through the transcriptional activation of p53 and repression of TCF/LEF in gastric cancer. 24931004

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines. 24587255

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The combined results of immunohistochemistry and proteomic analysis suggest that H. pylori altered the p53 and 14-3-3 isoforms expression and DENA further enhanced the H. pylori effect, which might be involved in carcinogenesis and metastasis of gastric cancer on Gulo(-/-) mice. 24035909

2014