Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE We also found that miR-532-5p level was negatively correlated with RUNX3 gene expression in various GC cell lines. 26515139

2017

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The SNPs of ITGA5-1160/ITGB1-1949/ ITGB1 + 31804 as T/A/C carriers and COX-2-1195/IL-10-592 as G-carrier/AA, or more specific to combine RUNX3 + 492/TFF2-308 as A-carrier/CC shall be host factor predisposing to gastric cancer during H. pylori infection, and serve as marker to identify high-risk subjects for H. pylori eradication. 25884934

2016

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In this study, we investigated the role of miRNAs targeting RUNX3 in early tumorigenesis. miR-130a and miR-495 upregulated under hypoxic conditions that bind to the RUNX3 3'-untranslated region (3'-UTR) were identified in gastric cancer cells by using microarray analysis and bioinformatics programs. 26375442

2016

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE More than a decade ago claims arose that the RUNX3 member of the RUNX transcription factor family is a major TSG inactivated in gastric cancer, a postulate extended later to other cancers. 25641675

2015

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer. 25088199

2015

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric cancer cells. 24447545

2015

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells. 24447505

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer. 23549984

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE RUNX3 inhibits survivin expression and induces cell apoptosis in gastric cancer. 24636883

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE RUNX3 appears to be a novel suppressor of HIF-1α and of hypoxia-mediated angiogenesis in gastric cancer cells. 23542169

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer. 23774402

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. 22231444

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2. 23243425

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Antitumor activity of cell-permeable RUNX3 protein in gastric cancer cells. 23230322

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The frequencies of high-level methylation in GC tissues for the seven genes were: 48% for APC, 57.33% for WIF-1, 56% for RUNX-3, 50.67% for DLC-1, 52% for SFRP-1, 54.67% for DKK, and 48% for E-cad. 23049225

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Evaluation of the relationship between dietary factors, CagA-positive Helicobacter pylori infection, and RUNX3 promoter hypermethylation in gastric cancer tissue. 23555166

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The current findings supported RUNX3 methylation as a risk factors for the carcinogenesis of chronic atrophic gastritis with H. pylori infection and indicated that circulating RUNX3 methylation is a valuable biomarker for the detection of early GC. 22576578

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE We carried out a case-control study in an Omani Arab population to investigate the association between gastric cancer and peripheral blood leukocyte DNA methylation in LINE-1 and in the tumor suppressor genes CDH1, p16, TP53 and RUNX3. 22126203

2012

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Increased genetic susceptibility to intestinal-type gastric cancer is associated with increased activity of the RUNX3 distal promoter. 21523770

2012

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1. 21128246

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of gastric cancer. 21135153

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). 21328447

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC). 21205319

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE In gastric cancer, a new epigenetic mechanism of tumour suppressor loss has been suggested where the histone methyltransferase enhancer of zeste homolog 2 (EZH2) is responsible for loss of expression of RUNX3. 20631058

2010

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. 20176475

2010