Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE In this study, we investigated the role of methylation in reduced XPC in melanoma. 29373959

2018

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE Expression of GGR components XPC, DDB1 and DDB2 was significantly lower in melanoma after UVB. 27487145

2016

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma. 26427666

2016

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE In addition, there was some evidence of publication bias in the meta-analysis, and meta-analyses of the studies with large sample size did not find the obvious association between XPC Lys939Gln polymorphism and cutaneous melanoma risk in Caucasians. 24277375

2014

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. 23650282

2013

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma. 23568549

2013

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Severe XPA and XPC cause innumerable carcinomas and melanomas in light-exposed eyes and skin, and enhanced risk of visceral cancers. 23622385

2013

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE Melanoma risk was higher in individuals carrying the complete XPC haplotype than each individual polymorphism (OR 3.64; 95% CI 1.77-7.48). 21733660

2011

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE ORs for XPD and XPC genotypes were stronger for melanoma diagnosed at an early age, but tests for interaction were not statistically significant. 16258177

2006

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 healthy cancer-free sex-matched Caucasian control subjects from the same area. 15731165

2005

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE We investigated the role of three variant alleles of the DNA repair gene XPC and one variant allele of the XPG gene in a hospital-based case-control study of 294 Caucasian patients from Germany with malignant melanoma and 375 healthy control individuals from the same area matched by sex. 15494739

2005