Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 AlteredExpression BEFREE Besides, a number of related indicators suggested that Loureirin A has a strong antioxidant activity in the treatment of osteoarthritis via increasing content of SOD2 and suppressing MDA and ROS. 31784401

2020

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 AlteredExpression BEFREE SOD2 expression was lower in OA tissues, but higher in normal joint tissues.AURKA interference activates SOD2. 30811038

2019

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 GeneticVariation BEFREE The finding in mice that deletion of SOD2 or the anti-oxidant gene transcriptional regulator nuclear factor-erythroid 2- related factor (Nrf2) result in more severe OA, while overexpression or treatment with mitochondrial targeted anti-oxidants reduces OA, further support a role for excessive ROS in the pathogenesis of OA. 30176344

2019

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 AlteredExpression BEFREE Expression of Nrf2 and its target genes HO-1, NQO1 and SOD2 was significantly high in OA cartilage compared to normal cartilage and was also higher in damaged area compared to smooth area of OA cartilage of the same patient. 29339024

2018

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 Biomarker BEFREE Instead, Wogonin induced mild oxidative stress through the generation of ROS and depletion of cellular GSH, thereby modulating the cellular redox leading to the induction of Nrf2/ARE pathways through activation of ROS/ERK/Nrf2/HO-1-SOD2-NQO1-GCLC signaling axis in OA chondrocytes. 28237856

2017

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 Biomarker BEFREE SOD2 depletion led to a significant increase in mtDNA strand breaks in chondrocytes, but there was no notable difference in the level of strand breaks between OA and control chondrocytes. 23138846

2013

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 AlteredExpression BEFREE Serum levels of SOD2 appeared statistically increased in OA patients when compared with healthy controls (p < 0.001). 22108257

2011

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.380 PosttranslationalModification BEFREE The SOD2 promoter had significant DNA methylation alterations in OA cartilage. 20511611

2010