Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 Biomarker BEFREE These emerging OA drugs such as bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-18 (FGF-18), human serum albumin (HSA), interleukin-1 (IL-1) inhibitor, β-Nerve growth factor (β-NGF) antibody, matrix extracellular phosphoglycoprotein (MEPE) and inverse agonist of retinoic acid-related orphan receptor alpha (RORα) etc. have shown potential to modify progression of OA with minimal adverse effects. 31312184

2019

Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 Biomarker BEFREE Here, we review the involvement of FGFs in bone-related processes and diseases; FGF1 in the differentiation of human bone marrow mesenchymal stem cells and fracture repair; FGF2, FGF9, and FGF18 in osteoarthritis; FGF6 in bone and muscle injury; FGF8 in osteoarthritis and Kashin-Beck disease; and FGF21 and FGF23 on bone regulation. 31260189

2019

Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 Biomarker BEFREE Ten of the likely effector genes, including TGFB1 (transforming growth factor beta 1), FGF18 (fibroblast growth factor 18), CTSK (cathepsin K), and IL11 (interleukin 11), have therapeutics approved or in clinical trials, with mechanisms of action supportive of evaluation for efficacy in osteoarthritis. 30664745

2019

Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 Biomarker BEFREE Our study proved that FGF18 might be a promising drug for the treatment of early stage osteoarthritis and is worth further study. 30273654

2019

Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 Biomarker BEFREE One promising factor for these applications is sprifermin, a human-recombinant fibroblast growth factor-18, which stimulates chondrocyte proliferation and matrix synthesis and is in clinical trials for the treatment of osteoarthritis. 31393594

2019

Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 Biomarker BEFREE Fibroblast growth factor (FGF) 18 has been shown to increase cartilage volume when injected intra-articularly in animal models of osteoarthritis (OA) and in patients with knee OA (during clinical development of the recombinant human FGF18, sprifermin). 28823647

2017

Entrez Id: 8817
Gene Symbol: FGF18
FGF18
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.370 AlteredExpression BEFREE Knockdown of TCF7L2 isoforms in mouse chondrocytes rescued hedgehog signaling-induced Fgf18 downregulation, while overexpression of the human dnTCF7L2 orthologue (dnTCF4) in human chondrocytes promoted the expression of catabolic enzymes associated with OA. 27018594

2016