Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The reliance on Akt2 and TGF beta signaling may also potentiate the case for Akt inhibitors or small molecule inhibitors of TGFbeta signaling like doxycycline as adjunct chemotherapy in serous ovarian carcinoma, especially the metastatic variants. 25894377

2016

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. 25733895

2015

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The restoration of SFRP5 downregulated AKT2 and sensitized ovarian cancer cells to chemotherapy. 19957335

2010

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer. 16584837

2007

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE This review examines a number of proto-oncogenes and tumor suppressor genes that are associated with ovarian carcinomas, including p53, BRCA1, and BRCA2; mismatch repair genes such as hMSH2 and hMLH1; and PTEN, HER-2/neu, K-ras, fms, and AKT2. 11123866

2005

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The proliferation-related function of AKT2 and SEI-1 suggests that both genes are likely to be biological targets of an amplification event at 19q13.1 in ovarian cancer and to play important roles in ovarian tumorigenesis. 12499249

2003

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE To determine how AKT2 might contribute to tumor cell progression, a full-length, wild-type, human AKT2/protein kinase B (PKB)beta cDNA was transfected into a panel of eight human breast and ovarian cancer cells. 12517798

2003

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE In addition, downstream effectors of PI3-kinase, AKT1 and AKT2, have been found to be amplified or activated in human tumours, including ovarian cancer. 9916799

1999

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Several proto-oncogenes, such as AKT2 and Ki-RAS, are activated during ovarian cancer development, with putative oncogene-containing chromosomal regions showing imbalances and DNA amplifications. 9633840

1998

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE We previously demonstrated that the putative oncogene AKT2 is amplified and overexpressed in some human ovarian carcinomas. 8622988

1996

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. 1409633

1992