Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407006
Gene Symbol: MIR221
MIR221
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.050 AlteredExpression BEFREE In conclusion, crocin showed promising neuroprotective effects in ROT-induced PD via activation of PI3K/Akt/mTOR axis and enhanced miRNA-7 and miRNA-221. 31811872

2020
Entrez Id: 407006
Gene Symbol: MIR221
MIR221
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.050 Biomarker BEFREE In conclusion, these results demonstrated that downregulation of SNHG1 attenuated MPP<sup>+</sup>-induced decreases in LC3-II (an autophagic marker) levels and cytotoxicity through the miR-221/222/p27/mTOR pathway, suggesting that SNHG1 may be a therapeutic target for neuroprotection and disease treatment in PD. 31499060

2019
Entrez Id: 407006
Gene Symbol: MIR221
MIR221
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.050 Biomarker BEFREE Yet the molecular mechanism linking miR-221 to genetic forms of PD has not been studied. 30107296

2018
Entrez Id: 407006
Gene Symbol: MIR221
MIR221
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.050 Biomarker BEFREE Furthermore, the receiver operating characteristic result of serum miR-221 for prediction of PD was 0.787. 27748571

2016
Entrez Id: 407006
Gene Symbol: MIR221
MIR221
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.050 AlteredExpression BEFREE We hypothesized that microRNA 221 could regulate the expression of TfR2 in an in vitro model of Parkinson's disease, SH-SY5Y cells treated with MPP⁺. 24055409

2013