Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.030 GeneticVariation BEFREE Accompanying this improvement was correction of activity in the p38 MAPK-TSC-Rheb-mTORC1-S6K1 pathway. 30928642

2019
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.030 Biomarker BEFREE ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. 21813464

2011
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.030 Biomarker BEFREE It was proposed that abrogation of a newly identified mTOR-mediated negative feedback regulation on extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway and on the well-documented RTK-PI3K-AKT signaling cascade could limit the efficacy of mTOR inhibitors in the treatment of TSC patients. 19539245

2009