Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.050 Biomarker BEFREE Accompanying this improvement was correction of activity in the p38 MAPK-TSC-Rheb-mTORC1-S6K1 pathway. 30928642

2019
Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.050 Biomarker BEFREE Taken together, our study demonstrates that Myo1b mediates the effect of Arg-II in activating mTORC1-S6K1 through promoting peripheral lysosomal positioning, that results in spatial separation and thus dissociation of TSC from lysosome, leading to hyperactive mTORC1-S6K1 signaling linking to cellular senescence/apoptosis. 29472548

2018
Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.050 AlteredExpression BEFREE Collectively, these data strongly suggest that FMRP S499 phosphorylation is independent of mTORC1-S6K1 activity and is not altered in TSC. 24806451

2014
Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.050 AlteredExpression BEFREE Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity. 18487611

2008