Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 Biomarker BEFREE We conducted further optimization of dual enzymatic inhibitions towards FGFR1 and DDR2, two important kinases in lung squamous cell carcinoma. 30572178

2019
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 GeneticVariation BEFREE A total of 11 patients harboring a DDR2 mutation was detected among the 271 sequenced lung SCC samples (4%). 29129434

2018
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 GeneticVariation BEFREE Although Forced expression of DDR2 and its mutant (T681I) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model. 28676216

2017
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 GeneticVariation BEFREE Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients. 24885564

2014
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 Biomarker BEFREE In lung squamous cell carcinoma (lung SqCC), recent studies have suggested that DDR2 mutations are a biomarker for therapeutic response to dasatinib and clinical trials are underway testing this hypothesis. 24296828

2014
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 GeneticVariation BEFREE Ten of 215 pure SQCCs (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2, and EGFR. 24158231

2014
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 Biomarker BEFREE More recently oncogenic drivers, such as DDR2, FGFR1 and PI3KCA, have been characterized in squamous cell lung carcinoma (SCC) and target agents are currently under evaluation. 23930754

2013
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 GeneticVariation BEFREE Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung. 22586316

2011
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.490 GeneticVariation BEFREE A squamous cell lung cancer patient with a response to dasatinib and erlotinib treatment harbored a DDR2 kinase domain mutation. 22328973

2011