Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.060 AlteredExpression BEFREE However, no significant associations of p16 expression with the overall survival and progression-free survival of nasopharynx cancer were found. 30882625

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.060 AlteredExpression BEFREE Is human papillomavirus and p16 expression associated with survival outcomes in nasopharyngeal cancer?: A systematic review and meta-analysis. 30029797

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.060 Biomarker BEFREE The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests. 29664911

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.060 Biomarker BEFREE P16 INK4A status predicts better outcome in laryngeal, hypopharyngeal or nasopharyngeal cancer cases treated with surgery plus adjuvant radiochemotherapy as well as with definitive radiation therapy and/or chemotherapy. 25640361

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.060 AlteredExpression BEFREE EZH2 regulates the expression of p16 in the nasopharyngeal cancer cells. 23289480

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.060 Biomarker BEFREE Increased frequencies at p<0.01 were found for antibodies to p16 in breast, esophageal, and nasopharyngeal cancer as well as HCC. 17016600

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk. 24114013

2014

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Significant associations between GSTM1/GSTT1 polymorphisms and nasopharyngeal cancer risk. 23275251

2013

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Meta-analysis of GSTM1 and GSTT1 polymorphisms and risk of nasopharyngeal cancer. 23679259

2013

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Association between GSTM1 polymorphism and nasopharyngeal cancer susceptibility: a meta-analysis. 23317262

2012

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Polymorphisms in GSTM1, GSTTI and GSTP1 and nasopharyngeal cancer in the east of China: a case-control study. 22393996

2011

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE GSTM1 and GSTT1 polymorphisms and nasopharyngeal cancer risk: an evidence-based meta-analysis. 19338664

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE TP53 codon 72 polymorphism contributes to nasopharyngeal cancer susceptibility: a meta-analysis. 19608020

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE We evaluated the linkage of the polymorphic variants (Arg/Pro) on TP53 codon 72 with nasopharyngeal cancer development in a case-control study with 392 individuals from a northern Portuguese population, including 107 patients with nasopharyngeal carcinoma and 285 healthy controls. 16835507

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Although point mutations in the p53 gene are observed in nasopharyngeal cancer, the mutation rate is lower than in other tumors. 15523893

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.050 GeneticVariation BEFREE Three p53 DNA polymorphisms (BstUI and MspI RFLPs in exon 4 and intron 6, respectively, and a 16-bp duplication in intron 3) and their haplotype combinations were studied in 73 patients (61 males and 12 females) with nasopharyngeal cancer and 105 healthy controls from the Guizhou province in southern China. 8825463

1996

Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 AlteredExpression BEFREE Is human papillomavirus and p16 expression associated with survival outcomes in nasopharyngeal cancer?: A systematic review and meta-analysis. 30029797

2019

Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 AlteredExpression BEFREE However, no significant associations of p16 expression with the overall survival and progression-free survival of nasopharynx cancer were found. 30882625

2019

Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 GeneticVariation BEFREE Significant associations between GSTM1/GSTT1 polymorphisms and nasopharyngeal cancer risk. 23275251

2013

Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 GeneticVariation BEFREE Meta-analysis of GSTM1 and GSTT1 polymorphisms and risk of nasopharyngeal cancer. 23679259

2013

Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 AlteredExpression BEFREE EZH2 regulates the expression of p16 in the nasopharyngeal cancer cells. 23289480

2013

Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 GeneticVariation BEFREE The study was performed to assess the potential role of GSTM1, GSTT1 and GSTP1 polymorphisms in the risk of nasopharyngeal cancer in Chinese population. 22393996

2011

Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 GeneticVariation BEFREE GSTM1 and GSTT1 polymorphisms and nasopharyngeal cancer risk: an evidence-based meta-analysis. 19338664

2009

Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.040 Biomarker BEFREE Increased frequencies at p<0.01 were found for antibodies to p16 in breast, esophageal, and nasopharyngeal cancer as well as HCC. 17016600

2006

Entrez Id: 108004545
Gene Symbol: LOC108004545
LOC108004545
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.030 Biomarker BEFREE NCSCs were enriched from human nasopharyngeal cancer cell lines CNE2 and HONE1 through tumorsphere-forming assay. 31342620

2019