Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial 		0.320 GeneticVariation BEFREE We conclude that DNA mismatch repair defects involving hMLH1 and hMSH2 underexpression are extremely rare events in sporadic and familial breast cancer. 14520695

2003
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial 		0.320 GeneticVariation BEFREE Four specific epigenetic lesions, promoter hypermethylation of the DNA mismatch repair gene hMLH1, the DNA alkyl-repair gene O(6)-methylguanine-DNA methyltransferase (MGMT), the detoxifier glutathione S-transferase P1 (GSTP1) and the familial breast cancer gene BRCA1 may lead to four specific genetic lesions, microsatellite instability, G to A transitions, steroid-related adducts and double-strand breaks in DNA. 11094302

2000