×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Gastrin has been shown to stimulate pancreatic cancer in an autocrine fashion.31268978 2019
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Polyclonal Ab Stimulator (PAS) is a vaccine that targets gastrin and has been shown to prolong survival of patients with pancreatic cancer .
31549214 2019
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
This study suggests that inhibition of the cancer-promoting effects of gastrin in pancreatic cancer can decrease metastases by altering the TME and decreasing pathways that activate the epithelial mesenchymal transition.
31433212 2019
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear.
29717112 2018
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Gastrin could serve as an effective therapeutic target for the metastasis of pancreatic cancer .27264047 2016
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
GeneticVariation
BEFREE
One important factor that contributes to increased colon and pancreatic cancer risk is gastrin .
26820391 2016
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer through the CCK-B receptor (CCK-BR).
25469546 2015
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Gastrin stimulates the growth of pancreatic cancer cells through the activation of the cholecystokinin-B receptor (CCK-BR), which has been found to be overexpressed in pancreatic cancer .22442157 2012
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Growth of human pancreatic cancer is stimulated by gastrin through the CCKBR and an alternatively spliced isoform of the CCKBR gene called CCKCR.
22277584 2012
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
αv integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion.
22110279 2011
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
AlteredExpression
BEFREE
Although down-regulation of gastrin inhibits growth of pancreatic cancer , the contribution of endogenous CCK to tumor growth is unknown.
21186400 2011
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
These results suggest that RNAi targeting of gastrin could serve as an effective treatment for pancreatic cancer .
19465883 2009
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
These studies demonstrate that gastrin and the CCK-C receptor form an autocrine loop in human pancreatic cancer that plays a role in regulating growth.
14749036 2004
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
The gastrointestinal peptides gastrin and cholecystokinin (CCK) stimulate growth of human pancreatic cancer by a receptor-mediated process.
12429993 2002
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
It has been assumed that gastrin stimulates the growth of pancreatic cancer in an autocrine way through co-expression of gastrin and the cholecystokinin-B receptor (CCK-BR).
11444473 2001
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Antisense oligonucleotide to gastrin may have a role in the future treatment of patients with pancreatic cancer .
10077228 1999
×
Entrez Id: 2520
Gene Symbol: GAST
GAST
Malignant neoplasm of pancreas
0.100
Biomarker
BEFREE
Gastrin has been shown to stimulate growth of human pancreatic cancer , and does so in an autocrine fashion.9855703 1998