Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.010 GeneticVariation BEFREE Case-control comparisons were adjusted for ancestry-informative principal components, and top associations from the discovery analysis underwent replication in an independent dataset of 657 cases and 1,183 controls.<b>Results:</b> Three highly correlated HLA class II variants (<i>r</i><sup>2</sup> = 0.33-0.98) were associated with osteosarcoma risk in discovery analyses, including <i>HLA-DRB1*0301</i> (OR = 0.52; <i>P</i> = 3.2 × 10<sup>-3</sup>), <i>HLA-DQA1*0501</i> (OR = 0.74; <i>P</i> = 0.031), and <i>HLA-DQB1*0201</i> (OR = 0.51; <i>P</i> = 2.7 × 10<sup>-3</sup>). 30038050

2018