Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE Do estrogen, progesterone, P53 and Ki67 receptor ratios determined from curettage materials in endometrioid-type endometrial carcinoma predict lymph node metastasis? 31395281

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE We evaluate CD274 (PD-L1), CDKN2A (p16), tumor protein p53 (TP53), and epidermal growth factor receptor (EGFR) immunoexpression in primary tumors, recurrences and lymph node metastases and its correlations with prognosis and HPV status. 31844270

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE The expressions of ER, CD34 and p53 in the cancer tissue of case group were correlated with the existence of calcification, spicule sign and lymph node metastasis detected by Doppler ultrasound (p<0.05), but not associated with tumor diameter and morphology (p>0.05). 29745079

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE The T1/T2-4 ratio, the frequency of small cancers (diameter ≤2-4 cm), and<unterline></unterline> intestinal mucin expression were higher in cluster B than in cluster A, but there were no significant differences in the frequencies of MMR silencing, mutant p53 pattern, and lymph node metastasis between the 2 clusters. 30625481

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE Apparent Diffusion Coefficient Histogram Analysis for Assessing Tumor Staging and Detection of Lymph Node Metastasis in Epithelial Ovarian Cancer: Correlation with p53 and Ki-67 Expression. 30456593

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE Abnormal p53 status was associated with advanced Federation of Gynecology and Obstetrics stage, lymph node metastases, DFS and DSS (P<0.05, Fisher exact test). 31335355

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE Differentially regulated miRNAs were validated in the TCGA lung adenocarcinoma patients with p53 mutations and, subsequently, we identified specific miRNA signatures that are associated with lymph node metastasis and poor survival of the patients. 31661871

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE Further studies found that the high CRYAB and p53 co-expression was also significantly correlated with pathological grade (<i>P</i>=0.024), lymph node metastasis (<i>P</i>=0.000), Distant metastasis (<i>P</i>=0.015), TNM stage (<i>P</i>=0.013), and survival (<i>P</i>=0.000). 31152111

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE The correlation between clinicopathological parameters, MMR expression, p53 status, and LNM status was determined using chi-squared tests and logistic analysis. 30774439

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE We found that LNM is associated with (i) specific hotspot somatic mutations in TP53 and CASP8; (ii) rare nonsilent germline mutations in BRCA2 and FAT1; (iii) mutations in mito-G2/M and nonhomologous end joining (NHEJ) pathways; (iv) recurrent deletion of genes for DNA repair by homologous recombination; and (v) chromosomal instability. 30924133

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE Results of x2 test showed that the positive rate of p53 protein was significantly correlated with cervical space-occupying lesion and mass diameter shown in transvaginal color Doppler ultrasound (p<0.05), but it had no significant correlation with pelvic lymph node metastasis (p>0.05). 30003750

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE ARID1B expression was associated with lymph node metastasis status, histological grade and p53 expression. 30867762

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE CT scan combined with the detection of p53 and c-Myc expressions can improve the diagnosis of lymph node metastasis and clinical staging for patients with NSCLC, which is conducive to the clinical treatment and prognosis analysis of NSCLC. 29364480

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE Consequently, in TNBC patients who received adjuvant chemotherapy, immunohistochemical p53 expression was associated with better BCSS in N0 patients. 30527200

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE Dual expression of immunoreactive estrogen receptor β and p53 is a potential predictor of regional lymph node metastasis and postoperative recurrence in endometrial endometrioid carcinoma. 29190668

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE However, breast cancer was not significantly correlated with lymph node metastasis (OR = 1.19, 95%CI = 0.83 - 1.70, P = 0.35), Progesterone Receptor (PR) status (OR = 1.08, 95%CI = 0.58 - 2.00, P = 0.81), Human epidermal growth factor receptor - 2(HER-2/neu)status (OR = 1.01, 95%CI = 0.65 - 1.57, P = 0.97), P53 mutation (OR = 1.30, 95%CI = 0.76 - 2.21, P = 0.34) and age > 50 (OR = 1.07, 95%CI = 0.46 - 2.51, P = 0.88). 28848211

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE The expression of UBE2C was positively correlated with tumor size (r = 0.32, P < 0.001), histological grade (r = 0.237, P = 0.001), clinical stage (r = 0.198, P = 0.004), lymph node metastasis (r = 0.155, P = 0.026), HER2 expression level (r = 0.356, P < 0.001), Ki-67 expression level (r = 0.504, P < 0.001), and P53 expression level (r = 0.32, P = 0.001). 29021715

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE TUG1 expression was significantly downregulated in both breast cancer tissues and cell lines compared to controls, and low TUG1 expression was significantly correlated with mutant p53 expression (p=0.037) and lymph node metastasis (p=0.044). 28950664

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE In this case study, the immunophenotype of a distinctive low grade endometrioid adenocarcinoma with an unusual pattern of lymph node metastases is used to explore the possible roles for underlying TP53-related molecular events in its pathogenesis. 29137657

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE The positive expression rate of EZH2 and p53 protein in SCC patients with and without lymph node metastasis was 82.9 and 70.4% (EZH2) and 45.7 and 34.7% (p53), respectively, which was also a significant difference (P < 0.05). 27323178

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE We evaluated whether KRAS and TP53 mutations are associated with pathologic complete response (pCR) and lymph node metastasis after adjusting for neoadjuvant regimen. 27020587

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. 26619844

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression BEFREE Increased p53 expression significantly correlated with high pathological grade and lymph node metastasis in EC specimens. 25697482

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 Biomarker BEFREE The aim of the present study was to evaluate the relationship between primary oral cancer and lymph node metastasis in a series of patients with synchronous and metachronous metastases by 2 clonality tests: mt-DNA and TP53 sequence analysis. 25530302

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation BEFREE Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP53-mutation status for patient stratification and identify associations of an immune response-related gene expression cluster and TP53 mutations with lymph node metastasis in HNSCC. 26095926

2015