Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Moreover, the identification of EGFR as a transcriptional regulator of PTHLH in neuroblastoma provides a novel therapeutic opportunity to promote a less aggressive tumor phenotype through irreversible inhibition of EGFR tyrosine kinase activity. 31293052

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE We have previously shown that UBE4B levels are inversely correlated with EGFR levels in neuroblastoma tumors. 31475882

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Vasoactive intestinal polypeptide receptor 1 (VPAC1) and epidermal growth factor receptor (EGFR) are associated with signal transduction pathways relevant to neuroblastoma, cancer of breast, prostate and lungs. 30810849

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In two independent orthotopic human neuroblastoma xenograft models, short-term studies (28 days) of tumor-bearing mice led to a significant decrease in tumor size in <sup>EGFR</sup>EDV<sup>TM</sup><sub>Dox</sub>-treated animals compared to control, doxorubicin, or non-EGFR EDV<sup>TM</sup><sub>Dox</sub> There was increased TUNEL staining of tumors at day 28 compared to control, doxorubicin, or non-EGFR EDV<sup>TM</sup><sub>Dox</sub> Moreover, overall survival was increased in neuroblastoma mice treated with <sup>EGFR</sup>EDV<sup>TM</sup><sub>Dox</sub> (<i>P</i> < 0007) compared to control. 29491149

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Taken together, these results show that afatinib inhibits neuroblastoma growth both in vitro and in vivo by suppressing EGFR-mediated PI3K/AKT/mTOR signaling. 27902463

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Applying a systematic pairwise drug combination screen we observed a highly potent synergy in neuroblastoma cells between the EGFR kinase inhibitor lapatinib and the anticancer compound YM155 that is preserved across several neuroblastoma variants. 28596528

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Neuroblastoma expressed a novel EGFR mutant which possesses distinct biologic and biochemical properties that might have therapeutic implications. 27216155

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Clinically, EGFR inhibitors are ineffective as single agent compounds in patients with recurrent NB, likely due to this transferred survival dependence to Bcl(-)2. 25756510

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncogene homolog (KRAS), phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen activated protein kinase kinase 1 (MEK1), phosphatase and tensin homolog (PTEN), and human epidermal growth factor receptor 2 (HER2) in patient specimens and cell line DNA. 24823994

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The discovery of anti-EGFR resistance in the setting of Kirsten rat sarcoma viral oncogene (KRAS) and more recently, neuroblastoma RAS viral oncogene (NRAS) mutations in CRC has changed the focus of therapy for metastatic disease to one based on the molecular characteristics of the tumor. 25374966

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE The effects of the EGFR inhibitor cetuximab were examined in neuroblastoma cells that expressed wild-type and mutant UBE4B. 22990745

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations. 22135231

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE EGFR, PI3Kp110 and PTEN expression is a common feature of NB. 21225506

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE EGFR expression and gene mutation were studied by reversetranscriptase-polxmerase chain reacting, fluorescence-activated cell sorting and gene sequencing in six neuroblastoma cell lines. 19414383

2009

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The EGFR-targeted antibody and growth factor toxins scFv(14E1)- Pseudomonas exotoxin A (ETA) and TGF-alpha-ETA exerted anti-cancer effects in neuroblastoma cell lines that were insensitive to cetuximab or EGFR tyrosine kinase inhibitors. 18927293

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Here, we show that TGFalpha, a known activator of Ras signaling, can drive cell proliferation and at the same time induce the expression of the Notch target Hes-1 in the neuroblastoma cell line SK-N-BE(2)c. The up-regulation of Hes-1 occurred both at the transcriptional and protein levels and by use of EGFR and MEK inhibitors we could show that the Hes-1 response was dependent on activation of the MAP kinase ERK. 16120441

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE CRAds expressing p53 and targeted towards EGFR appear promising new agents for local control in the treatment of neuroblastoma. 15651070

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Gene amplification and rearrangements are discussed through review of recent work on the N-myc gene in neuroblastoma and the epidermal growth factor receptor (EGFR) gene in glioblastoma. 3059215

1988

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Increased epidermal growth factor receptor in multidrug-resistant human neuroblastoma cells. 2464605

1988