Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling. 31100410

2019

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma. 31608140

2019

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Altogether, these results define the ERK-ETV5-RET pathway as a critical axis driving neuroblastoma oncogenesis downstream of activated ALK. 29321660

2018

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells. 29496180

2018

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In our previous study, both trametinib (MEK inhibitor) and CH5126766 (RAF/MEK inhibitor) showed in vitro antitumor effects on neuroblastoma cells with ERK phosphorylation (pERK). 30266481

2018

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Induction of MEK/ERK activity by AZD8055 confers acquired resistance in neuroblastoma. 29571732

2018

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK. 30541014

2018

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE We evaluated the response of neuroblastoma cell lines to MEK-ERK pathway inhibition by trametinib. 29184034

2017

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE These data reveal that cearoin induces autophagy, ERK activation and apoptosis in neuroblastoma SH-SY5Y cells, which is mediated primarily by ROS generation, suggesting its therapeutic application for the treatment of neuroblastomas. 28178193

2017

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Clearance of Damaged Mitochondria Through PINK1 Stabilization by JNK and ERK MAPK Signaling in Chlorpyrifos-Treated Neuroblastoma Cells. 26892626

2017

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects. 26993602

2016

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE We identified β-estradiol and MAPK/ERK as having functional cross-talk with MYCN and being novel targetable vulnerabilities of MYCN-amplified neuroblastoma. 26673823

2015

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE A cell-based assay was developed using natively expressed ORL-1 receptors on mouse neuroblastoma cells to measure phosphorylated ERK as a reporter of agonist-induced receptor activation and intracellular signaling. 25677767

2015

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrowth increased upon Cbl-b depletion in several neuroblastoma cell lines. 25921289

2015

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Thus, EGFR regulates Mcl(-)1 dependence in high-risk NB via ERK-mediated phosphorylation of Bim such that EGFR/ERK inhibition renders Mcl(-)1 dependent tumors now reliant on Bcl(-)2. 25756510

2015

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 PosttranslationalModification BEFREE GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. 24550142

2014

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Inhibition of ERK1 activity using pharmacologic inhibitors of mitogen-activated ERK kinase (MEK1/2) showed significant synergistic growth inhibitory activity when combined with GSK923295 in neuroblastoma, lung, pancreatic and colon carcinoma cell lines. 22948716

2013

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells. 19241161

2009

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 PosttranslationalModification BEFREE Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain. 18809477

2008

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Taken together, these results show that TGFalpha is a potent mitogen of neuroblastoma cells and suggest a connection between activation of ERK and Hes-1, thus providing a link between the Ras and Notch signaling pathways. 16120441

2005

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 PosttranslationalModification BEFREE Remarkably knock-down of WOX1 expression by small interfering RNA in neuroblastoma SK-N-SH cells spontaneously induced Tau phosphorylation at Thr212/Thr231 and Ser515/Ser516, enhanced phosphorylation of glycogen synthase kinase 3beta (GSK-3beta) and ERK, and enhanced NFT formation. 15126504

2004

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE SH-SY5Y neuroblastoma cells exposed to the complex I inhibitor/parkinsonian neurotoxin methylpyridinium ion (MPP(+)) activate both survival and death-promoting signaling pathways and undergo MEK/ERK-dependent, phosphatidylinositol-3 kinase-dependent, and c-Jun kinase-dependent cell death. 12710931

2003

Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Interestingly, several neuroblastoma cell lines with 1p deletion and one SCLC cell line express DRT transcripts of aberrant size (i.e. 8589679

1995