Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.050 AlteredExpression BEFREE Analysis of the gene expression profiles of breast tumours revealed that the highest expression levels of CXCR4 and CXCR7 were in the Claudin-Low molecular subtype, which is markedly associated with EMT features. 29541196

2018
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.050 Biomarker BEFREE Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. 29257351

2018
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.050 Biomarker BEFREE Furthermore, genetic silencing or pharmacologic inhibition of CXCR7 reduced breast tumor growth and metastasis. 24886617

2014
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.050 Biomarker BEFREE We used dual luciferase imaging to investigate CXCR7-dependent scavenging of CXCL12 in breast tumors in vivo and quantify effects of CXCR7 on tumor growth and metastasis of a separate population of CXCR4+ breast cancer cells. 22266857

2012
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.050 Biomarker BEFREE These data also provide support for distinct biological functions of CXCR4 and CXCR7 and suggest that targeting CXCR4 and/or CXCR7 would have distinct molecular effects on ER-positive breast tumors. 21695171

2011