Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE One factor, which may drive ongoing matrix synthesis in breast tumors, is the loss of stromal caveolin-1 (cav-1), a scaffolding protein of caveolae, which has been linked to breast tumor aggressiveness. 28187162

2017
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 PosttranslationalModification BEFREE Cav1 CGI shore methylation was also observed in human breast tumors, and overall survival rates of breast cancer patients lacking estrogen receptor α (ERα) negatively correlated with Cav1 expression. 23128390

2013
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression BEFREE Importantly, in vivo experiments employing xenograft tumor models demonstrated that expression of caveolin-1 results in significant growth inhibition of breast tumors. 18778685

2008
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058

2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE We investigated the function of caveolin-1 protein in breast tumors. 14506991

2003
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo. 10086342

1999