×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Characterization of the c.793-1G > A splicing variant in CHEK2 gene as pathogenic: a case report.
31349801 2019
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families.
28608266 2018
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA-repair gene mutations in prostate cancer.
29368341 2018
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer.
29520813 2018
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
27798748 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
CHEK2 c.1100delC mutation is associated with an increased risk for male breast cancer in Finnish patient population.
28874143 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
27798748 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Colorectal cancer risk associated with the CHEK2 1100delC variant.
28734145 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Genomic analysis of inherited breast cancer among Palestinian women: Genetic heterogeneity and a founder mutation in TP53.
28486781 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.
28495237 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2.
27616075 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.
28008555 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients.
28724667 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study.
28125075 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes.
28944238 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing.
27696107 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.
28008555 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Rare, protein-truncating variants in ATM , CHEK2 and PALB2 , but not XRCC2 , are associated with increased breast cancer risks.
28779002 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Sensitivity of BRCA1/2 testing in high-risk breast/ovarian/male breast cancer families: little contribution of comprehensive RNA/NGS panel testing.
27273131 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.
26884562 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.
27153395 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients.
26822949 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
27433846 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
27595995 2016