Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8553
Gene Symbol: BHLHE40
BHLHE40
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.510 Biomarker CTD_human A group of haplotypes overlapping BHLHE40 was associated with non-24-hour sleep-wake cycles, and less robustly, with delayed sleep and bipolar disorder (e.g., rs34883305, rs34870629, rs74439275, and rs3750275 were associated with n=37, p=4.58E-09, Bonferroni p=2.95E-06). 25395965

2014
Entrez Id: 8553
Gene Symbol: BHLHE40
BHLHE40
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.510 Biomarker PSYGENET We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls. 20072116

2010
Entrez Id: 8553
Gene Symbol: BHLHE40
BHLHE40
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.510 Biomarker PSYGENET A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with BP (P = 0.00000172). 18228528

2008