Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2312
Gene Symbol: FLG
FLG
CUI: C0013595
Disease: Eczema
Eczema 		0.700 Biomarker CTD_human We found three additional rare null mutations in this case series, suggesting that the genetic architecture of filaggrin-related atopic dermatitis consists of both prevalent and rare risk alleles. 17417636

2007
Entrez Id: 2312
Gene Symbol: FLG
FLG
CUI: C0013595
Disease: Eczema
Eczema 		0.700 Biomarker GENOMICS_ENGLAND Here we show that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis. 16550169

2006
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0013595
Disease: Eczema
Eczema 		0.420 Biomarker GENOMICS_ENGLAND Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses. 31235509

2019
Entrez Id: 929
Gene Symbol: CD14
CD14
CUI: C0013595
Disease: Eczema
Eczema 		0.390 Biomarker CTD_human Carriers of the CD14-159C/T and IL4Ralpha I75V single-nucleotide polymorphisms (SNPs) had an increased risk of eczema at both ages 2 and 3 (OR=3.44, 95% CI: 1.56-7.57), especially among children who were SPT+. 19759553

2010
Entrez Id: 3572
Gene Symbol: IL6ST
IL6ST
CUI: C0013595
Disease: Eczema
Eczema 		0.310 Biomarker GENOMICS_ENGLAND Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses. 31235509

2019