Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946

2017

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. 27117003

2016

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. 25352456

2015

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. 25714973

2015

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model. 22507317

2012

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity. 18227305

2008

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. 17962197

2008

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. 17573346

2007

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785

2007

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. 16449385

2006

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. 16651627

2006

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Pick bodies in a family with presenilin-1 Alzheimer's disease. 15622541

2005

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset
0.300 Biomarker CTD_human Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. 7596406

1995