Source: GWASCAT

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.410 GeneticVariation GWASCAT Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. 30643255

2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.130 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.120 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.110 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 29785
Gene Symbol: CYP2S1
CYP2S1
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 553103
Gene Symbol: MIR3936HG
MIR3936HG
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 60468
Gene Symbol: BACH2
BACH2
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 27086
Gene Symbol: FOXP1
FOXP1
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 8809
Gene Symbol: IL18R1
IL18R1
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 2879
Gene Symbol: GPX4
GPX4
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 745
Gene Symbol: MYRF
MYRF
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.100 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019