Source: GWASDB

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease
1.000 GeneticVariation GWASDB Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. 22137330

2013

Entrez Id: 5621
Gene Symbol: PRNP
PRNP
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease
1.000 GeneticVariation GWASDB Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. 19081515

2009

Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB SNCA_ rs356220 was associated with both Sporadic-PD (OR = 1.37, P = 1 × 10(-9)) and Familial-PD (OR = 1.40, P = 2 × 10(-5)). 24511991

2014

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669

2013

Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278

2013

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233

2012

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB In all, the 16 replicated and newly discovered loci, in addition to the three coding NOD2 variants, accounted for 11.2% of the total genetic variance for CD risk in the AJ population. 22412388

2012

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation GWASDB A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. 21980299

2012

Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.900 GeneticVariation GWASDB Age at the onset of motor symptoms in Huntington disease (HD) is determined largely by the length of a CAG repeat expansion in HTT but is also influenced by other genetic factors. 22387017

2012

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation GWASDB Eleven of 52 non-MHC T1D loci showed evidence of association with at least one autoantibody at a false discovery rate of 16%: 16p11/IL27-IA-2A, 2q24/IFIH1-IA-2A and PCA, 2q32/STAT4-TPOA, 10p15/IL2RA-GADA, 6q15/BACH2-TPOA, 21q22/UBASH3A-TPOA, 1p13/PTPN22-TPOA, 2q33/CTLA4-TPOA, 4q27/IL2/TPOA, 15q14/RASGRP1/TPOA, and 12q24/SH2B3-GADA and TPOA. 21829393

2011

Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)). 21874001

2011

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463

2010

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB Among the 116,161 single-nucleotide polymorphisms tested, an association with the known CD susceptibility gene NOD2, the 5q31 haplotype, and the recently reported CD locus at 5p13.1 was confirmed. 17684544

2010

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. 20570966

2010

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation GWASDB Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480

2010

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177

2010

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 20070850

2010

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB Association to PD at SNCA was replicated in the Japanese GWAS, confirming this as a major risk locus across populations. 19915575

2010

Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation GWASDB This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD. 20070850

2010

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0019569
Disease: Hirschsprung Disease
Hirschsprung Disease
0.900 GeneticVariation GWASDB RET is a well-established susceptibility locus, although existing evidence strongly suggests additional loci contributing to sporadic HSCR. 19196962

2009

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 17435756

2008

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.900 GeneticVariation GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394

2008