|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These data indicate that odor identification impairments observed in schizophrenia are influenced by the COMT val158met polymorphism.
|
22148860 |
2012 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia.
|
16542182 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MEDLINE search (12/31/11) yielded 14 studies examining the association of the COMT gene polymorphism (rs4680) and aggression in schizophrenia (total n=2219).
|
22784685 |
2012 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase (COMT) Val158Met polymorphism has been identified as a potential etiologic factor in schizophrenia.
|
18092319 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia.
|
17448448 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It is possible that the COMT Val(158)Met polymorphism therefore contributes to the development of these neuropsychological and brain structural endophenotypes of schizophrenia, in which the prefrontal cortex may represent the neural substrate underlying both n-back and CPT performances.
|
23527885 |
2013 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between COMT Val(158)Met genotype and RTV do not appear to reflect transmission of schizophrenia liability in families.
|
16815691 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Unfortunately, these studies have produced conflicting results.In a previous report, Shifman et al. found a three-marker haplotype (rs737865-rs4680-rs165599) that showed significant association with schizophrenia.
|
17427186 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study sought to clarify the effects of the COMT Val158Met polymorphism on brain structure, function, and risk of developing schizophrenia in a well-characterized cohort of individuals at high risk of schizophrenia for familial reasons.
|
17014827 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.
|
27020768 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The <i>COMT</i> Val 108/158 Met polymorphism (rs4680) may affect treatment response to antipsychotics, as well as metabolism and dynamics of neurotransmitters during the treatment of schizophrenia.
|
29950847 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia.
|
17383818 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we explored the relationship between the Val158Met polymorphism of the COMT gene and the GMV/cortical thickness/cortical surface area in 150 first-episode treatment-naïve patients with schizophrenia and 100 healthy controls.
|
25564193 |
2015 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Does COMT val158met polymorphism influence P50 sensory gating, eye tracking or saccadic inhibition dysfunctions in schizophrenia?
|
27825784 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia.
|
17113268 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia.
|
15583953 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotypic variations in the functional polymorphism Val(158)Met COMT appear to have an impact in dopamine signaling in the PFC of healthy subjects and schizophrenia patients.
|
27421706 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Psychiatry 57 (2005)1117-1127) who found association between schizophrenia/schizophreniform disorder and homozygosity at the high activity Val variant of rs4680.
|
21310591 |
2011 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia.
|
28273278 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility.
|
14754787 |
2004 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Aggression behavior in patients with schizophrenia can be indicated by positive BOLD-fMRI values in the lower CNS and negative values in the high-level CNS and by a recessive gene model in <i>COMT</i> polymorphism rs4680.
|
28223811 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia.
|
26999687 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain.
|
15098000 |
2004 |