|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It exists as common high and low activity alleles in the population (determined by a valine 158 methionine polymorphisms), and high red blood cell activity of COMT has previously been associated with schizophrenia.
|
9323320 |
1997 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide.
|
11150892 |
2001 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings provide independent support for the hypothesis that the catechol-O-methyltransferase Val(158)Met polymorphism influences neurocognitive function in schizophrenia, and suggest that the functional effects may be expressed on measures of Processing Speed and Attention.
|
12372660 |
2002 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the relationship of catechol-O-methyltransferase Val158Met and monoamine oxidase A promoter repeat polymorphism with response to conventional neuroleptic treatment in schizophrenia.Ninety-four schizophrenic patients formed 2 different study populations.
|
14520117 |
2003 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia.
|
12963670 |
2003 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility.
|
14754787 |
2004 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain.
|
15098000 |
2004 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val158Met polymorphism did not appear to significantly affect susceptibility, symptomatology, global cognitive function and prognosis in Chinese patients with schizophrenia, but the possible association with AOO merits further investigation.
|
15118357 |
2004 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene influences prefrontal cognitive function and increases the risk for schizophrenia.
|
15169701 |
2004 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Increased catechol-O-methyltransferase activity associated with variation in catechol-O-methyltransferase valine158 methionine genotypes may result in reduced dopamine neurotransmission in the prefrontal cortex and thus contribute to the poor performance of frontally mediated cognitive tasks and the occurrence of associated negative symptoms observed in patients with schizophrenia; however, reported associations between catechol-O-methyltransferase valine158 methionine genotypes and measures of cognition have not been consistent.
|
15450787 |
2004 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia.
|
15583953 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val(158)Met polymorphism shared 6.6% of the executive/attention dysfunction variance in patients with schizophrenia and 15.6% of the motor impairment variance in patients with deficit schizophrenia.
|
16037677 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-OCD.
|
16043283 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow.
|
15668720 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this study does not support the hypothesis that the 158 Val/Met polymorphism in the COMT gene is associated with schizophrenia in Koreans.
|
16109444 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attention and positive symptoms in schizophrenia, it was further hypothesized that Absorption is associated with the VAL158MET polymorphism of the catechol-O-methyltransferase (COMT) gene affecting the dopaminergic neurotransmitter system.
|
15965969 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While it cannot be determined whether TBI influenced the association of COMT Val158Met to executive functioning, these data extend the known relationship of genotype to executive performance seen in healthy comparison subjects and individuals with schizophrenia to individuals with TBI.
|
16387984 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the genetic contribution of other COMT variants to SZ susceptibility, we investigated three single-nucleotide polymorphisms (SNPs) (rs737865, rs4633, rs165599) in addition to the Val/Met variant (rs4680) in a highly selected sample of Australian Caucasian families containing 107 patients with SZ.
|
15505638 |
2005 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia.
|
16542182 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between COMT Val(158)Met genotype and RTV do not appear to reflect transmission of schizophrenia liability in families.
|
16815691 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered promoter methylation and the nature of the contribution of COMT Val158Met polymorphism as risk factors for schizophrenia and bipolar disorder by analyzing 115 post-mortem brain samples from the frontal lobe.
|
16984965 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives.
|
17071544 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.
|
16952445 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia.
|
16330500 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT Val(158)Met) is associated with prefrontal-dependent task performance in schizophrenia.
|
16691129 |
2006 |