|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study.
|
25665738 |
2015 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population.
|
25913043 |
2015 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified that <i>STAT4</i>-rs7574865 polymorphism was significantly associated with an increased risk of HCC in allelic contrast, dominant, homozygote and recessive models.
|
30310516 |
2018 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P = 1.79 × 10(-2), OR = 1.17, 95% CI = 1.03-1.34; rs9267673: P = 4.91 × 10(-4), OR = 1.37, 95% CI = 1.15-1.63; rs2647073: P = 3.53 × 10(-5), OR = 1.63, 95% CI = 1.29-2.06; rs3997872: P = 4.22 × 10(-4), OR = 1.86, 95% CI = 1.32-2.62; rs9275319: P = 1.30 × 10(-2), OR = 1.32, 95% CI = 1.06-1.64).
|
26538132 |
2015 |
|
rs7574865
|
|
Liver carcinoma
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively).
|
23242368 |
2013 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present study also indicates that <i>STAT4</i> rs7574865 polymorphism increased the risk of chronic HBV infection and HCC.
|
31160486 |
2019 |
|
rs7574865
|
|
Liver carcinoma
|
G |
0.900 |
GeneticVariation
|
GWASDB |
The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively).
|
23242368 |
2013 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data demonstrated positive association of rs7574865 with HCC risk when compared to healthy controls under an additive model (GG versus TT: odds ratio (OR) =2.07, 95% confidence interval (CI)=1.06-4.03, P=0.033).
|
26745093 |
2015 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR=0.84, 95%CI=0.7-0.99, P=0.048 and OR=0.7, 95%CI=0.5-0.99, P=0.047).
|
23748017 |
2013 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In contrast, STAT4-rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk.
|
30289982 |
2019 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significantly increased risk of HCC associated with the rs7574865</span> G was found.
|
27126090 |
2017 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62-1.19; meta-analysis, OR = 0.87, 95%CI = 0.74-1.03), which may be due to the small sample size.
|
25365208 |
2014 |
|
rs7574865
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively).
|
23242368 |
2013 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development.
|
27998720 |
2017 |
|
rs2596542
|
|
Liver carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC.
|
29731972 |
2018 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Studying SNP rs2596542C/T association with HCC and LC susceptibility revealed that statistical significant differences (<i>P</i> = 0.013, <i>P</i> = 0.027) were only observed between SNP rs2596542C/T and each of HCC and LC, respectively, versus healthy controls, indicating that the rs2596542C/T genetic variation is not a significant contributor to HCC development in LC patients.
|
28417047 |
2017 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC.
|
31419949 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population.
|
23665287 |
2013 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19).
|
23024757 |
2012 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma.
|
28427234 |
2017 |