|
rs1001179
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, we did not find any statistically significant differences in rates between CAT rs1001179 and CTSD rs17571 genotypes and AD controlling for APOE e4 allele status.
|
18248894 |
2008 |
|
rs10046
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our results demonstrated that homozygous TT genotype in rs10046, dominant AA and AG genotypes in rs767199, homozygous TT genotype in rs727479, and dominant TT and TA genotypes in rs1143704 might be the susceptibility genotypes for AD, while no associations were observed between rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms and AD susceptibility.
|
31278540 |
2019 |
|
rs10051644
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated that the T-A-C-A-T-C-C and T-G-C-A-T-C-C haplotypes in the southwestern cohort and the T-G-C-G-C-T-C haplotype in the eastern cohort, consisting of rs10051644, rs6869634, rs3797617, rs3756577, rs4958445, rs10515639 and rs6881743, showed a significant association with AD (<i>P</i> = 0.037, <i>P</i> = 0.026 and <i>P</i> = 0.045, respectively).
|
31031618 |
2019 |
|
rs10085109
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the four SNPs, rs10085109 in the FLT4 gene was only significantly associated with the AD phenotype in both initial and replication samples.
|
23490417 |
2013 |
|
rs1008805
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between rs10046, rs1143704, rs767199, rs727479, rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms in aromatase (CYP19A1) gene and Alzheimer's disease risk: a systematic review and meta-analysis involving 11,051 subjects.
|
31278540 |
2019 |
|
rs10097505
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further luciferase assay, data mining, and integrative analyses revealed that the AD-risk genotype AA of rs10097505 was associated with an increased Arc mRNA expression and an elevated Aβ level.
|
28108859 |
2018 |
|
rs1010159
|
|
Alzheimer's Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the MCI cohort, rs1010159 was associated with conversion to AD (HR = 1.56, p = 0.002).
|
25881907 |
2015 |
|
rs1010159
|
|
Alzheimer's Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
We conducted a study of 7 single nucleotide polymorphisms (SNPs), rs668387, rs689021, rs641120, rs1699102, rs3824968, rs2282649, and rs1010159, in the SORL1 gene that were associated to AD in previous studies.
|
19584446 |
2009 |
|
rs1010159
|
|
Alzheimer's Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations.
|
29036834 |
2018 |
|
rs1010159
|
|
Alzheimer's Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.
|
19368828 |
2009 |
|
rs10137185
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A separate SNP (rs10137185) was associated with decreased risk for AD in women who identified themselves as Black (OR 0.6, 95% CI = 0.4-0.9).
|
24326520 |
2014 |
|
rs10139154
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current study provides preliminary </span>evidence of the involvement of SCFD1 rs10139154 in the risk of developing AD.
|
31267315 |
2019 |
|
rs10164112
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in combination with the <i>APOE</i> ε4 allele, the rs10164112-T allele has been found to be a risk factor for AD in the Han Chinese population reported in this study.
|
30666118 |
2019 |
|
rs10173717
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this cohort, we identified novel loci genome-wide significantly associated as modifiers of the age of onset of AD (CD44, rs187116, P=1.29 × 10⁻¹²; NPHP1, rs10173717, P=1.74 × 10⁻¹²; CADPS2, rs3757536, P=1.54 × 10⁻¹⁰; GREM2, rs12129547, P=1.69 × 10⁻¹³, among others) as well as other loci known to be associated with AD.
|
22710270 |
2013 |
|
rs1022442
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two genes found to be near the top SNPs, CYP19A1 (rs2899472, p = 1.90 × 10(-7)) and NCAM2 (rs1022442, p = 2.75 × 10(-7)) have been reported as genetic factors related to the progression of AD from previous studies.
|
20932310 |
2010 |
|
rs1024611
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed the associations between the baseline plasma MCP-1 level, longitudinal cognitive changes, and genetic effects of CCL2 rs1024611 and its receptor, CC-chemokine receptor 2 (CCR2) rs1799864, in AD.
|
29352259 |
2018 |
|
rs1035071612
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In addition, the C766T polymorphism was shown not to influence the age onset of AD.
|
15925094 |
2005 |
|
rs1035071612
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The C-allele of the silent C766T polymorphism in exon 3 of the LRP gene might be associated with AD, however, results are conflicting and thus discussed controversially.
|
12898587 |
2003 |
|
rs1035071612
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data suggested that the polymorphism of LRP C766T was strongly associated with AD and T allele might be a protective factor for AD in Chinese Han population.
|
18706476 |
2008 |
|
rs1035071612
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Recently, several studies have reported a correlation between a polymorphism (C766T) in exon 3 of LRP and AD.
|
10027548 |
1999 |
|
rs1035071612
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The LRP C766T polymorphism is protective against Alzheimer's disease, perhaps through alteration of LRP expression.
|
9832203 |
1998 |
|
rs1035071612
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the present study, we have investigated the extent of amyloid beta protein (Abeta) deposition as cerebral amyloid angiopathy (CAA) or senile plaques (SP) in relationship to OLR1 +1071 and +1073 polymorphisms and LRP1 C766T polymorphism in patients with AD There was an increased Abeta40 load as CAA, but not as SP, in frontal cortex of AD patients carrying OLR1+1073 CC genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele.
|
16328515 |
2006 |
|
rs1036819
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to a ptau/Aβ42 rQTL and association with AD case/control status, rs1036819 is a strong rQTL for case/control status/Aβ42 and for tau/Aβ42.
|
30153862 |
2018 |
|
rs1038162399
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
|
26988102 |
2016 |
|
rs10399931
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of the CHI3L1 gene (rs4950928 C>G and rs10399931 C>T) are associated with the risk and prognosis of AD and can affect the expression of CHI3L1 in plasma.
|
30223258 |
2019 |