|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first study to show significant association between rs744373 polymorphism and AD in East Asian population.
|
23570733 |
2013 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Mutants in rs1800587 of IL-1A, rs1143634 of IL-1B, rs12989701, and rs744373 of BIN1 were significantly associated with AD onset.
|
26768592 |
2017 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.
|
25630570 |
2015 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown.
|
30992433 |
2019 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The Bridging Integrator 1 Gene Polymorphism rs744373 and the Risk of Alzheimer's Disease in Caucasian and Asian Populations: An Updated Meta-Analysis.
|
26846281 |
2017 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a subsequent promoter analysis, we found the single nucleotide polymorphism rs744373 C-allele to be associated with high mRNA levels of bridging integrator 1 (BIN1)/Amphiphysin 2, i.e. a major component of the endocytotic machinery and located in a crucial genetic AD risk locus.
|
26631617 |
2016 |
|
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a total of 2816 AD cases and 2706 controls, we unambiguously replicated the association of rs744373 (for BIN1) and rs541458 (for PICALM) polymorphisms with the AD risk (odds ratio [OR] = 1.26, 95% confidence interval [CI] [1.15-1.38], p = 2.9 × 10(-7), and OR = 0.80, 95% CI [0.74-0.88], p = 4.6 × 10(-7), respectively).
|
21220176 |
2011 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".
|
26972434 |
2016 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
|
25359311 |
2015 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians.
|
20951388 |
2011 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.
|
20697030 |
2010 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods.
|
23572399 |
2013 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially.
|
27048444 |
2017 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD.
|
25169757 |
2014 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
|
23650005 |
2013 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship.
|
30039188 |
2018 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup.
|
23040034 |
2013 |
|
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |