|
rs1048943
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of the present study suggest that CYP1A1 Ile462Val polymorphism might be a low-penetrant risk factor for acute leukemia.
|
23056546 |
2012 |
|
rs1048943
|
|
Acute periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
|
31032950 |
2019 |
|
rs1048943
|
|
Acute respiratory failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
The final model which included >5 risk alleles in the CYP1A1 (rs2606345, rs4646903, rs1048943), GCLC, AGT, and AGTR1 genes was associated with pleuritis, empyema, acute respiratory distress syndrome, all PC and acute respiratory failure (ARF).
|
24068433 |
2013 |
|
rs1048943
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
|
16195240 |
2006 |
|
rs1048943
|
|
Adenocarcinoma of lung (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphism (Ile/Val, Val/Val) was 2.99 [95% confidence interval (95%CI) 1.51-5.91]; this effect was stronger on lung adenocarcinoma (OR 4.85, 95%CI 2.03-11.6).
|
12771031 |
2003 |
|
rs1048943
|
|
Adenocarcinoma of lung (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of lung adenocarcinoma in never-smoking Korean women, whereas specific combinations of variant genotypes for metabolic enzymes increase lung cancer risk considerably.
|
17980933 |
2008 |
|
rs1048943
|
|
Adenocarcinoma of lung (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk in a case-control study of 198 patients and 152 control subjects.
|
12163326 |
2002 |
|
rs1048943
|
|
Aggressive Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
|
31032950 |
2019 |
|
rs1048943
|
|
Aggressive periodontitis, generalized
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hyperlipidemia could modulate the effect of CYP1A1 rs1048943 on the periodontal status of GAgP.
|
31032950 |
2019 |
|
rs1048943
|
|
Anxiety
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ETS-exposed group with both the CYP1A1 MspI and the CYP1A1 Ile462Val variants had higher scores, as reflected in total CBCL score as well as scores on the internalizing scale and its emotional subdomain, the anxious scale, and the externalizing scale and its aggressive subdomain.
|
20855412 |
2010 |
|
rs1048943
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val) on asthma risk and ETS exposure, we recruited 201 unrelated children and classified them into four groups: (1) control without ETS exposure; (2) control with ETS exposure; (3) with asthma and with ETS exposure and (4) with asthma and without ETS exposure.
|
22236719 |
2012 |
|
rs1048943
|
|
Bile duct carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 95% confidence interval (CI), 1.3-3.0] and bile duct cancers (OR = 1.8, 95% CI = 1.1-3.1), whereas the CYP1A1 Ex7 + 131 (rs1048943) G allele was associated with ampulla of Vater cancer (OR = 2.9, 95% CI = 1.5-5.4).
|
19168589 |
2009 |
|
rs1048943
|
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population.
|
23886208 |
2013 |
|
rs1048943
|
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate a possible association of the CYP1A1 Ile462Val and GSTM1 null polymorphisms with the risk of developing bladder cancer in a Turkish population.
|
21709011 |
2011 |
|
rs1048943
|
|
Bone neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allelic variation frequency of the CYP1A1 gene at exon 7 (Ile 462 Val) in bone tumor patients was 0.462, which was significantly higher than that in the normal controls (0.223).
|
26681006 |
2015 |
|
rs1048943
|
|
Brain Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The increased risk of brain tumors was evident for CYP1A1 rs2606345 (P = 0.0028; OR = 2.06; 95 % CI, 1.27-3.34) and minor haplotypes rs2606345-rs1048943-rs4646903 in females (global haplotype association P value, 0.0011).
|
23661361 |
2013 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The objective of this study was to assess the association between M2 (A2455G, Ile462Val) and M4 (C2453A, Thr461Asn) polymorphisms in CYP1A1 and breast cancer risk among Jordanian women and in subgroups stratified by menopausal status and smoking history.
|
26838244 |
2016 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
No association was found between any CYP1A1 Ile462Val polymorphism and breast cancer.
|
17603290 |
2007 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We here carried out a population based case-control study of the CYP MspI (CYP1A1*1/M1) and Ile462Val (CYP1A1*2/M2) polymorphisms in CYP1A1 to clarify their importance in determining breast cancer susceptibility in a South Indian population.
|
22292665 |
2011 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk.
|
17063266 |
2007 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms CYP1A1 rs1048943, CYP1B1 rs1056836, COMT rs4680, GSTP1 rs1695, GSTT1 null and GSTM1 null which are involved in estrogen metabolism pathway.
|
23000097 |
2013 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The genotype distribution of Ile462Val in controls was also close to that expected under HWE with no significant differences between breast cancer cases and the controls (P = 0.44).
|
11698341 |
2001 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.
|
20878621 |
2011 |
|
rs1048943
|
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The increased risk of breast cancer associated with E+P use was greater among women with at least one rare allele of the CYP1A1 Ile(462)Val, CYP1A1 MspI, CYP1B1 Asn(453)Ser, and PGR Val(660)Leu polymorphisms than among women homozygous for the common allele of these polymorphisms.
|
18628428 |
2008 |
|
rs1048943
|
|
Bronchogenic Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The '1.9 allele' is associated with an increased incidence of Kreyberg Type I bronchogenic carcinomas in Japan and has recently been correlated with a valine-to-isoleucine substitution at position 462 in the haeme-binding region.
|
1844873 |
1991 |