|
rs1048943
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
<b>Conclusion.</b> This meta-analysis revealed a clear association between rs104</span>8943 and rs4646903 polymorphisms of the <i>CYP1A1</i> gene but not between CYP1B1 rs10012, rs162549, rs1800440, and rs2551188 polymorphisms and the risk of PCa.
|
30765615 |
2019 |
|
rs1048943
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
<b>Conclusion.</b> This meta-analysis revealed a clear association between rs104</span>8943 and rs4646903 polymorphisms of the <i>CYP1A1</i> gene but not between CYP1B1 rs10012, rs162549, rs1800440, and rs2551188 polymorphisms and the risk of PCa.
|
30765615 |
2019 |
|
rs1048943
|
|
Malignant tumor of cervix
|
|
0.090 |
GeneticVariation
|
BEFREE |
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele effect model (1.83[1.57, 2.13]); in addition, rs1048943 (CYP1A1 A4889G) had a very strong association in the dominant and recessive effect model.
|
25928231 |
2015 |
|
rs1048943
|
|
Cervix carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele effect model (1.83[1.57, 2.13]); in addition, rs1048943 (CYP1A1 A4889G) had a very strong association in the dominant and recessive effect model.
|
25928231 |
2015 |
|
rs1048943
|
|
cervical cancer
|
|
0.090 |
GeneticVariation
|
BEFREE |
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele effect model (1.83[1.57, 2.13]); in addition, rs1048943 (CYP1A1 A4889G) had a very strong association in the dominant and recessive effect model.
|
25928231 |
2015 |
|
rs1048943
|
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hyperlipidemia could modulate the effect of CYP1A1 rs1048943 on the periodontal status of GAgP.
|
31032950 |
2019 |
|
rs1048943
|
|
ovarian neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians.
|
22733497 |
2012 |
|
rs1048943
|
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians.
|
22733497 |
2012 |
|
rs1048943
|
|
Malignant neoplasm of ovary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians.
|
22733497 |
2012 |
|
rs1048943
|
|
Non-Small Cell Lung Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A case-control study was carried out on 1,040 nonsmall cell lung cancer (NSCLC) cases and 784 controls to investigate three CYP1A1 variants, CYP1A1*2A (rs4646903; thymidine to cytosine substitution at nucleotide 3801 (3801T>C)), CYP1A1*2C (rs1048943; 2455A>G; substitution of isoleucine 462 with valine (exon 7)) and CYP1A1*4 (rs1799814; 2453C>A; substitution of threonine 461 with asparagine (exon 7)) using PCR restriction fragment length polymorphism methods.
|
19608585 |
2010 |
|
rs1048943
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published.
|
22359202 |
2012 |
|
rs1048943
|
|
Malignant neoplasm of stomach
|
|
0.030 |
GeneticVariation
|
BEFREE |
A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published.
|
22359202 |
2012 |
|
rs1048943
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped.
|
28273931 |
2017 |
|
rs1048943
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.060 |
GeneticVariation
|
BEFREE |
A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped.
|
28273931 |
2017 |
|
rs1048943
|
|
Hyperhomocysteinemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification CYP1A1 (rs2606345, rs4646903, and rs1048943), GSTM1 (Ins/del), GSTT1 (Ins/del), ABCB1 rs1045642); immune and inflammation response IL-6 (rs1800795), TNF-a (rs1800629), MBL2 (rs7096206), CCR5 (rs333), NOS3 (rs1799983), angiotensin-converting enzyme ACE (rs4340), and occlusive vascular disease/hyperhomocysteinemia MTHFR (rs1801133).
|
23107763 |
2013 |
|
rs1048943
|
|
Malignant neoplasm of mouth
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
rs1048943
|
|
Lip and Oral Cavity Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
rs1048943
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
An elevated risk of lung cancer was observed among individuals with the MspI CC (OR=1.7, 95 CI=0.9-3.3) and Ile(462)Val ValVal genotypes (OR=2.8, 95 CI=1.1-7.6).
|
15953982 |
2005 |
|
rs1048943
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
An elevated risk of lung cancer was observed among individuals with the MspI CC (OR=1.7, 95 CI=0.9-3.3) and Ile(462)Val ValVal genotypes (OR=2.8, 95 CI=1.1-7.6).
|
15953982 |
2005 |
|
rs1048943
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
An elevated risk of lung cancer was observed among individuals with the MspI CC (OR=1.7, 95 CI=0.9-3.3) and Ile(462)Val ValVal genotypes (OR=2.8, 95 CI=1.1-7.6).
|
15953982 |
2005 |
|
rs1048943
|
|
Penile hypospadias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of the distributions of SNPs in CYP1A1 and CYP17A1 genes showed that the mutant genotype CC (OR = 4.87) of CYP1A1 rs1048943, and mutant genotype CC (OR = 5.82), recessive genotype AC + CC (OR = 2.17) and allele C (OR = 1.77) of CYP17A1 rs4919686 significantly increased the risk of HS.
|
30858503 |
2019 |
|
rs1048943
|
|
Hypospadias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of the distributions of SNPs in CYP1A1 and CYP17A1 genes showed that the mutant genotype CC (OR = 4.87) of CYP1A1 rs1048943, and mutant genotype CC (OR = 5.82), recessive genotype AC + CC (OR = 2.17) and allele C (OR = 1.77) of CYP17A1 rs4919686 significantly increased the risk of HS.
|
30858503 |
2019 |
|
rs1048943
|
|
Acute periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
|
31032950 |
2019 |
|
rs1048943
|
|
Aggressive Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
|
31032950 |
2019 |
|
rs1048943
|
|
cervical cancer
|
|
0.090 |
GeneticVariation
|
BEFREE |
Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a North Indian population.
|
24657182 |
2014 |