|
rs5273
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.
|
12433707 |
2002 |
|
rs2066826
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variant alleles at two markers, rs20417 and rs2066826, which are located in the promoter and intron 6, respectively, were in strong linkage disequilibrium with each other (D'=0.97) and were associated with a higher prevalence of T2DM.
|
12920574 |
2003 |
|
rs20417
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variant alleles at two markers, rs20417 and rs2066826, which are located in the promoter and intron 6, respectively, were in strong linkage disequilibrium with each other (D'=0.97) and were associated with a higher prevalence of T2DM.
|
12920574 |
2003 |
|
rs367650109
|
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the D299G and T399I polymorphisms of the TLR-4 gene does not play a major role on the progression of carotid atherosclerosis.
|
15953129 |
2005 |
|
rs5273
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the COX-2 Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the COX-2 Val511Ala SNP may contribute to a reduced risk of colon cancer among African Americans.
|
16489533 |
2006 |
|
rs5273
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the COX-2 Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the COX-2 Val511Ala SNP may contribute to a reduced risk of colon cancer among African Americans.
|
16489533 |
2006 |
|
rs20417
|
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs20417
|
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs20417
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs689470
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs689470
|
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs689470
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs5275
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs5275 polymorphism in the 3' untranslated region of the PTGS2 gene was associated with a decrease in breast cancer risk.
|
17214885 |
2007 |
|
rs5275
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs5275 polymorphism in the 3' untranslated region of the PTGS2 gene was associated with a decrease in breast cancer risk.
|
17214885 |
2007 |
|
rs4648298
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped the five most common polymorphisms (rs20417, rs5277, rs20432, rs5275, and rs4648298) in the Nurses' Health Study (1,270 cases, 1,762 controls) to test the hypothesis that polymorphisms in PTGS2 are associated with breast cancer risk, using logistic regression analyses.
|
17214885 |
2007 |
|
rs4648298
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped the five most common polymorphisms (rs20417, rs5277, rs20432, rs5275, and rs4648298) in the Nurses' Health Study (1,270 cases, 1,762 controls) to test the hypothesis that polymorphisms in PTGS2 are associated with breast cancer risk, using logistic regression analyses.
|
17214885 |
2007 |
|
rs2745557
|
|
Malignant neoplasm of prostate
|
|
0.030 |
GeneticVariation
|
BEFREE |
Three SNPs demonstrated nominally statistically significant associations with prostate cancer risk, with the most compelling polymorphism (rs2745557) associated with a lower risk of disease (odds ratio (OR) GC vs GG=0.64; 95% confidence interval (CI): 0.49-0.84; P=0.002).
|
17609663 |
2007 |
|
rs2745557
|
|
Prostate carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Three SNPs demonstrated nominally statistically significant associations with prostate cancer risk, with the most compelling polymorphism (rs2745557) associated with a lower risk of disease (odds ratio (OR) GC vs GG=0.64; 95% confidence interval (CI): 0.49-0.84; P=0.002).
|
17609663 |
2007 |
|
rs5275
|
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
In PLCO, the Ex10 +837 T>C marker (rs5275) was initially associated with prostate cancer risk (P-trend = 0.02) but became non-significant after adjustment for multiple comparisons (P = 0.08); this SNP showed no association with prostate cancer risk in the Nutrition Cohort (P-trend = 0.54) or in an analysis pooling the two cohorts (P-trend = 0.20).
|
17999989 |
2008 |
|
rs5275
|
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In PLCO, the Ex10 +837 T>C marker (rs5275) was initially associated with prostate cancer risk (P-trend = 0.02) but became non-significant after adjustment for multiple comparisons (P = 0.08); this SNP showed no association with prostate cancer risk in the Nutrition Cohort (P-trend = 0.54) or in an analysis pooling the two cohorts (P-trend = 0.20).
|
17999989 |
2008 |
|
rs2745557
|
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs2745557 was preferentially transmitted in ASDs (p < 0.01) and that the GAAA haplotype was significantly associated with ASDs (p < 0.01).
|
18579107 |
2008 |
|
rs5275
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed two common genetic polymorphisms: of cyclooxygenase-2 (COX-2) (COX2.8473, rs5275) and prostaglandin EP2 receptor gene (uS5, rs708494) in patients with CAD.
|
18989535 |
2008 |
|
rs20417
|
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).
|
19046748 |
2009 |
|
rs20417
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We replicated the observation of the Atherosclerosis Risk in Communities Study and observed an interaction of rs20417 with aspirin use on myocardial infarction risk (p for interaction=0.03).
|
19046748 |
2009 |
|
rs20417
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).
|
19046748 |
2009 |